N-(4-Nitrophenyl)-L-leucinamide

Modify Date: 2025-08-25 13:00:03

N-(4-Nitrophenyl)-L-leucinamide structure	Common Name	N-(4-Nitrophenyl)-L-leucinamide
	CAS Number	4178-93-2	Molecular Weight	251.282
	Density	1.2±0.1 g/cm3	Boiling Point	454.5±30.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₇N₃O₃	Melting Point	88-90ºC
	MSDS	Chinese USA	Flash Point	228.7±24.6 °C
	Symbol	GHS07	Signal Word	Warning

Name	L-Leucine-p-nitroanilide
Synonym	More Synonyms

Density	1.2±0.1 g/cm3
Boiling Point	454.5±30.0 °C at 760 mmHg
Melting Point	88-90ºC
Molecular Formula	C₁₂H₁₇N₃O₃
Molecular Weight	251.282
Flash Point	228.7±24.6 °C
Exact Mass	251.126984
PSA	100.94000
LogP	1.83
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.589
InChIKey	AXZJHDNQDSVIDR-NSHDSACASA-N
SMILES	CC(C)CC(N)C(=O)Nc1ccc([N+](=O)[O-])cc1
Storage condition	2-8°C

N-(4-Nitrophenyl)-L-leucinamide MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H319
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36
Safety Phrases	S26-S36-S37
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2924299090

z-leu-pna

CAS#:1174-27-2

N-(4-Nitropheny...

CAS#:4178-93-2

Literature: Okada; Tsuda; Hirata; Nagamatsu; Okamoto Chemical and pharmaceutical bulletin, 1982 , vol. 30, # 11 p. 4060 - 4068

N-tert-butoxyca...

CAS#:114684-52-5

N-(4-Nitropheny...

CAS#:4178-93-2

Literature: Kawai, Yasushi; Matsuo, Takashi; Ohno, Atsuyoshi Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 4 p. 887 - 891

Precursor 2
CAS#:1174-27-2 z-leu-pna CAS#:114684-52-5 N-tert-butoxyca...
DownStream 4
CAS#:3303-55-7 H-Phe-Leu-OH CAS#:61-90-5 L-leucine CAS#:100-01-6 4-Nitroaniline CAS#:14486-16-9 Met-Leu

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

PLoS ONE 10(2) , e0115859, (2015)

Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to rapidly develop resistance to therapeutics drives an urgent need for the delivery of new drugs. The M...

Beta-phenyl cysteine: a leucine aminopeptidase inhibitor.

Pharmacol. Res. Commun. 16(6) , 533-8, (1984)

Beta-phenyl cysteine: a leucine aminopeptidase inhibitor. The kinetic parameters of the inhibition of the leucine aminopeptidase by beta-phenyl cysteine are reported in this communication.

Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors.

Mol. Divers. 17(1) , 123-37, (2013)

Aminopeptidase N (APN) inhibitors have been reported to be effective in treating of life threatening diseases including cancer. Validated ligand- and structure-based pharmacophore mapping approaches w...

Name: Ratio of catalytic constant to that of Michaelis-Menten constant for LTA4 hydrolase-c...
Source: ChEMBL
Target: N/A
External Id: CHEMBL849801

Name: Ratio kcat /Km (1/M 1/s)
Source: ChEMBL
Target: N/A
External Id: CHEMBL848575

Name: Kinetic parameter (Km) for hydrolysis of LTA4 hydrolase purified from human leukocyte...
Source: ChEMBL
Target: Leukotriene A-4 hydrolase
External Id: CHEMBL703854

Name: Kinetic parameter Vmax against LTA4 hydrolase purified from human leukocytes was dete...
Source: ChEMBL
Target: Leukotriene A-4 hydrolase
External Id: CHEMBL703856

Name: Michaelis-Menten constant of compound for Leukotriene A4 hydrolase catalyzed hydrolys...
Source: ChEMBL
Target: Leukotriene A-4 hydrolase
External Id: CHEMBL703855

Name: Activity at pig kidney LAP after 40 mins by Michaelis-Menten equation
Source: ChEMBL
Target: N/A
External Id: CHEMBL1763897

Name: Kinetic parameter kcat against LTA4 hydrolase purified from human leukocytes
Source: ChEMBL
Target: Leukotriene A-4 hydrolase
External Id: CHEMBL703860

Name: Maximum velocity of amino acid amides was tested as substrates for Leukotriene A4 hyd...
Source: ChEMBL
Target: Leukotriene A-4 hydrolase
External Id: CHEMBL703859

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MFCD00063681

EINECS 224-047-3

N-(4-Nitrophenyl)-L-leucinamide

h-leu-pna