Glabranin

Modify Date: 2025-08-20 20:22:44

Glabranin Structure
Glabranin structure
Common Name Glabranin
CAS Number 41983-91-9 Molecular Weight 324.370
Density 1.2±0.1 g/cm3 Boiling Point 545.9±50.0 °C at 760 mmHg
Molecular Formula C20H20O4 Melting Point N/A
MSDS N/A Flash Point 197.1±23.6 °C

 Use of Glabranin


Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus[1].Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein[2].

 Names

Name glabranin
Synonym More Synonyms

 Glabranin Biological Activity

Description Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus[1].Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein[2].
Related Catalog
References

[1]. Sánchez I, et al. Antiviral effect of flavonoids on the dengue virus. Phytother Res. 2000 Mar;14(2):89-92.

[2]. Ismail NA, et al. Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. Interdiscip Sci. 2017 Dec;9(4):499-511.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 545.9±50.0 °C at 760 mmHg
Molecular Formula C20H20O4
Molecular Weight 324.370
Flash Point 197.1±23.6 °C
Exact Mass 324.136169
PSA 66.76000
LogP 6.02
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.622
InChIKey DAWSYIQAGQMLFS-SFHVURJKSA-N
SMILES CC(C)=CCc1c(O)cc(O)c2c1OC(c1ccccc1)CC2=O

 Safety Information

Hazard Codes Xi

 GlabraninBioassay

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Name: Cytotoxicity against human KB cells at 20 uM after 72 hrs by neutral red staining
Source: ChEMBL
Target: KB
External Id: CHEMBL2168276
Name: Inhibition of Electrophorus electricus C2888 AChE using acetylthiocholine iodide as s...
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL2168279
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
Name: Potency index, ratio of physostigmine IC50 to test compound IC50 for human erythrocyt...
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL4774394
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
Name: Neuroprotective activity against H2O2-induced cell death in human PC12D cells at 0.5 ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4774392
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data
Name: Neuroprotective activity against H2O2-induced neuronal death in Sprague-Dawley rat pr...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4774386
Name: Neuroprotective activity against H2O2-induced neuronal death in Sprague-Dawley rat pr...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4774387
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 Synonyms

(2S)-5,7-Dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-2,3-dihydro-4H-chromen-4-one
(2S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenyl-2,3-dihydro-4H-chromen-4-one
Glabranin
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