SBC-115337
Modify Date: 2024-01-06 11:13:17
SBC-115337 structure
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Common Name | SBC-115337 | ||
|---|---|---|---|---|
| CAS Number | 423148-46-3 | Molecular Weight | 473.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H19N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SBC-115337SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2]. |
| Name | SBC-115337 |
|---|
| Description | SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.5 μM (PCSK9)[1] |
| In Vitro | The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2]. |
| References |
| Molecular Formula | C29H19N3O4 |
|---|---|
| Molecular Weight | 473.48 |