(-)-Gallocatechin gallate

Modify Date: 2024-01-02 18:02:52

(-)-Gallocatechin gallate structure	Common Name	(-)-Gallocatechin gallate
	CAS Number	4233-96-9	Molecular Weight	458.372
	Density	1.9±0.1 g/cm3	Boiling Point	909.1±65.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₈O₁₁	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	320.0±27.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of (-)-Gallocatechin gallate

(-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.

Name	(-)-Gallocatechin gallate
Synonym	More Synonyms

Description	(-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Flavonoids
In Vitro	The amount of (-)-Gallocatechin gallate does not differ in leaves of different stages, and the content is relatively low[1]. (−)-gallocatechin gallate in combination with active catechins ((−)-epigallocatechin gallate) has synergistic effects on the induction of apoptosis and inhibition of cell growth for PC-9 cells. (−)-gallocatechin gallate shows inhibitory effect on α-Glucosidase and DPPH, with IC50s of 30.2 μM and 12.2 μg/mL[2].
Cell Assay	Cell viability is examined by measuring the capability of cells to metabolize MTT to a purple formazan dye. Human liver cancer HepG2 cells are maintained in DMEM medium supplemented with 10% fetal bovine serum, 100 units/mL penicillin, and 50 units/mL streptomycin at 37°C in a humidified incubator with 5% CO2 atmosphere. Cells are seeded in 96-well tissue culture plates for 24 h and then incubated with the tested compounds at different concentrations for 72 h. After incubation, 25 μL MTT in 5 mg/mL PBS is added and incubated for 4 h. The medium is aspirated and replaced with 150 μL dimethyl sulfoxide (DMSO) to dissolve the formazan salt. The color intensity of the formazan solution, which reflects the cell growth condition, is measured at 570 nm using a microplate spectrophotometer.
References	[1]. Zhang LQ, et al. Accumulation of catechins and expression of catechin synthetic genes in Camellia sinensis at different developmental stages. Bot Stud. 2016 Dec;57(1):31. [2]. Zhou H, et al. C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities. Food Chem. 2017 Nov 15;235:227-233.

Density	1.9±0.1 g/cm3
Boiling Point	909.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₈O₁₁
Molecular Weight	458.372
Flash Point	320.0±27.8 °C
Exact Mass	458.084900
PSA	197.37000
LogP	2.08
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.857
Storage condition	2-8°C

(-)-Gallocatechin gallate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH9000000

CHEMICAL NAME :: Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)- 2H-1-benzopyran-3-yl ester, (2S-trans)-

CAS REGISTRY NUMBER :: 4233-96-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H18-O11

MOLECULAR WEIGHT :: 458.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-944

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DH9000000

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J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

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Benzoic acid, 3,4,5-trihydroxy-, (2S,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

(−)-Gallocatechin gallate

(-)-Gallocatechin gallate

(2S,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate

Gallocatechin gallate

MFCD00214298

GCG

[(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate

(-)-Gallocatechin 3-O-gallate

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (-)-Gallocatechin gallate
Price: ￥478.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (-)-Gallocatechin gallate
Price: $410.0/50mg $700.0/100mg $1200.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (-)-Gallocatechin gallate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: (-)-Gallocatechin gallate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: $79/10mM*1mLinDMSO

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(-)-Gallocatechin gallate

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