MS37452
Modify Date: 2024-01-10 19:26:47
MS37452 structure
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Common Name | MS37452 | ||
|---|---|---|---|---|
| CAS Number | 423748-02-1 | Molecular Weight | 398.452 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 628.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H26N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 334.1±31.5 °C | |
Use of MS37452MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells[1]. |
| Name | 1-[4-(2,3-Dimethoxy-benzoyl)-piperazin-1-yl]-2-m-tolyloxy-ethanone |
|---|---|
| Synonym | More Synonyms |
| Description | MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells[1]. |
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| Related Catalog | |
| Target |
CBX7[1] |
| In Vitro | MS37452 (125-500 μM; 12 hours) significantly increases INK4A/ARF transcript levels up to 25% and 60% for 250 μM and 500 μM, respectively, as compared to the DMSO control[1]. MS37452 (250 μM; 2 hours) treats human PC3 prostate cancer cells for 2 hours reducing CBX7 occupancy across the INK4A/ARF locus[1]. RT-PCR[1] Cell Line: PC3 cells Concentration: 125-500 μM Incubation Time: 12 hours Result: Up-regulated INK4A/ARF expression up to 25% and 60% for 250 μM and 500 μM, respectively. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 628.8±55.0 °C at 760 mmHg |
| Molecular Formula | C22H26N2O5 |
| Molecular Weight | 398.452 |
| Flash Point | 334.1±31.5 °C |
| Exact Mass | 398.184174 |
| LogP | 2.29 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.575 |
| Storage condition | 20°C |
| RIDADR | NONH for all modes of transport |
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| 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)ethanone |
| 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone |
| 1-[4-(2,3-Dimethoxy-benzoyl)-piperazin-1-yl]-2-m-tolyloxy-ethanone |
| Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)- |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: MS37452
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: MS37452
- Price: $650.0/100mg $1200.0/250mg $2500.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: MS37452
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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