DL-Threo-beta-Hydroxyaspartic Acid

Modify Date: 2024-01-02 12:56:25

DL-Threo-beta-Hydroxyaspartic Acid Structure
DL-Threo-beta-Hydroxyaspartic Acid structure
Common Name DL-Threo-beta-Hydroxyaspartic Acid
CAS Number 4294-45-5 Molecular Weight 149.10200
Density 1.738 g/cm3 Boiling Point 368.7ºC at 760 mmHg
Molecular Formula C4H7NO5 Melting Point >230ºC dec
MSDS Chinese USA Flash Point 176.8ºC

 Use of DL-Threo-beta-Hydroxyaspartic Acid


DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat[1][2].

 Names

Name D,L-threo-β-Hydroxy Aspartic Acid
Synonym More Synonyms

 DL-Threo-beta-Hydroxyaspartic Acid Biological Activity

Description DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat[1][2].
Related Catalog
References

[1]. A Klegeris,et al. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells.J Neuroimmunol.1997 Sep;78(1-2):152-61.  

[2]. Jessica Darman, et al. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.J Neurosci. 2004 Aug 25;24(34):7566-75.  

 Chemical & Physical Properties

Density 1.738 g/cm3
Boiling Point 368.7ºC at 760 mmHg
Melting Point >230ºC dec
Molecular Formula C4H7NO5
Molecular Weight 149.10200
Flash Point 176.8ºC
Exact Mass 149.03200
PSA 120.85000
Index of Refraction 1.583
Storage condition 20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
HS Code 2922509090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles30

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The SLC1 high-affinity glutamate and neutral amino acid transporter family.

Mol. Aspects Med. 34(2-3) , 108-20, (2013)

Glutamate transporters play important roles in the termination of excitatory neurotransmission and in providing cells throughout the body with glutamate for metabolic purposes. The high-affinity gluta...

A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid.

Amino Acids 35(2) , 507-10, (2008)

3-Hydroxyaspartic acid and its derivatives are found both in the free form and as peptide constituents in various microorganisms and fungi. Considering the biological importance of this amino acid and...

Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.

Biochemistry 49 , 5066-73, (2010)

The mechanism of wild-type and R37A mutant Pseudomonas dacunhae aspartate beta-decarboxylase (ABDC) was studied by rapid-scanning stopped-flow spectrophotometry. Mixing wild-type ABDC with 50 mM disod...

 Synonyms

DL-THREO-β-HYDROXYASPARTIC ACID
threo-2-Amino-3-hydroxysuccinic acid
DL-Threo-beta-Hydroxyaspartic Acid