Tetrahydrocoptisine
Modify Date: 2024-01-07 16:31:50
Tetrahydrocoptisine structure
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Common Name | Tetrahydrocoptisine | ||
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| CAS Number | 4312-32-7 | Molecular Weight | 323.34300 | |
| Density | 1.47g/cm3 | Boiling Point | 466.6ºC at 760mmHg | |
| Molecular Formula | C19H17NO4 | Melting Point | 221-222ºC | |
| MSDS | N/A | Flash Point | 142.5ºC | |
Use of TetrahydrocoptisineTetrahydrocoptisine is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.IC50 value:Target:in vitro: THC significantly inhibited LPS-induced TNF-α, interleukin-6(IL-6) and nitric oxide (NO) production. THC inhibited the production of TNF-α and IL-6 by down-regulating LPS-induced IL-6 and TNF-α mRNA expression [1].in vivo: Pretreatment with THC (i.p.) inhibited the paw and ear edema in the carrageenan-induced paw edema assay and xylene-induced ear edema assay, respectively. In the lipopolysaccharide (LPS)-induced systemic inflammation model, THC significantly inhibited serum tumor necrosis factor-alpha (TNF-α) release in mice [1]. Pretreatment of THC at doses of 10 and 20mg/kg bodyweight significantly attenuated the gastric lesions as compared to the ethanol group [2]. |
| Name | (.+-.)-Tetrahydrocoptisine |
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| Synonym | More Synonyms |
| Description | Tetrahydrocoptisine is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.IC50 value:Target:in vitro: THC significantly inhibited LPS-induced TNF-α, interleukin-6(IL-6) and nitric oxide (NO) production. THC inhibited the production of TNF-α and IL-6 by down-regulating LPS-induced IL-6 and TNF-α mRNA expression [1].in vivo: Pretreatment with THC (i.p.) inhibited the paw and ear edema in the carrageenan-induced paw edema assay and xylene-induced ear edema assay, respectively. In the lipopolysaccharide (LPS)-induced systemic inflammation model, THC significantly inhibited serum tumor necrosis factor-alpha (TNF-α) release in mice [1]. Pretreatment of THC at doses of 10 and 20mg/kg bodyweight significantly attenuated the gastric lesions as compared to the ethanol group [2]. |
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| Related Catalog | |
| References |
| Density | 1.47g/cm3 |
|---|---|
| Boiling Point | 466.6ºC at 760mmHg |
| Melting Point | 221-222ºC |
| Molecular Formula | C19H17NO4 |
| Molecular Weight | 323.34300 |
| Flash Point | 142.5ºC |
| Exact Mass | 323.11600 |
| PSA | 40.16000 |
| LogP | 2.73740 |
| Storage condition | 2-8℃ |
| HS Code | 2934999090 |
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Chelidamine |
| Trahydocoptisine |
| DL-Stylopine |
| DL-Tetrahydrocoptisine |
| TETRAHYDROCOPTISINE |