Filastatin
Filastatin structure
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Common Name | Filastatin | ||
|---|---|---|---|---|
| CAS Number | 431996-53-1 | Molecular Weight | 359.80700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H18ClN3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of FilastatinFilastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C18H18ClN3O3 |
|---|---|
| Molecular Weight | 359.80700 |
| Exact Mass | 359.10400 |
| PSA | 69.37000 |
| LogP | 4.04510 |
| InChIKey | PNECWWUOUHGWQG-UHFFFAOYSA-N |
| SMILES | Cc1ccc(C(=O)N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)cc1Cl |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H410 |
| Precautionary Statements | P261-P273-P305 + P351 + P338-P501 |
| Hazard Codes | Xi |
| RIDADR | UN 3077 9 / PGIII |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Filastatin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: Main uses of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone: Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1]. |
| Q: What is the SMILES notation of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: SMILES notation of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is Cc1ccc(C(=O)N2CCN(c3ccc([N+](=O)[O-])cc3)CC2)cc1Cl. |
| Q: What is the molecular formula of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: Molecular formula of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is C18H18ClN3O3. |
| Q: What is the InChIKey of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: InChIKey of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is PNECWWUOUHGWQG-UHFFFAOYSA-N. |
| Q: What is the English name of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: The English name of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone. |
| Q: What English synonyms does (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone have? |
| A: English synonyms of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone: Filastatin. |
| Q: What is the molecular weight of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: Molecular weight of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is 359.80700. |
| Q: What is the polar surface area (PSA) of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: Polar surface area (PSA) of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is 69.37000. |
| Q: What is the CAS number of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: CAS number of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is 431996-53-1. |
| Q: What is the LogP of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone? |
| A: LogP of (3-chloro-4-methylphenyl)(4-(4-nitrophenyl)piperazin-1-yl)methanone is 4.04510. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |