SKPin C1
Modify Date: 2025-08-22 19:49:36
SKPin C1 structure
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Common Name | SKPin C1 | ||
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| CAS Number | 432001-69-9 | Molecular Weight | 465.34100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H13BrN2O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SKPin C1Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.IC50 value: Target: Skp2 inhibitor; p27 regulatorin vitro: T47D cells treated with C1 (5 μM for 16 hours) displayedan increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 (Figure 5C right; p < 0.001 and p < 0.01, respectively) and correlates with increased p27 protein levels (Figure 5E left, S4A top right) [1]. |
| Name | 2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid |
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| Synonym | More Synonyms |
| Description | Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.IC50 value: Target: Skp2 inhibitor; p27 regulatorin vitro: T47D cells treated with C1 (5 μM for 16 hours) displayedan increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 (Figure 5C right; p < 0.001 and p < 0.01, respectively) and correlates with increased p27 protein levels (Figure 5E left, S4A top right) [1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C18H13BrN2O4S2 |
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| Molecular Weight | 465.34100 |
| Exact Mass | 463.95000 |
| PSA | 137.12000 |
| LogP | 3.64680 |
| Storage condition | -20℃ |
| skp2 inhibitor |
| Skp2 Inhibitor C1 |