JKC 363 TFA

Modify Date: 2024-01-08 10:32:57

JKC 363 TFA structure	Common Name	JKC 363 TFA
	CAS Number	436083-30-6	Molecular Weight	1506.708
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₉H₉₁N₁₉O₁₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JKC 363 TFA

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

Name	jkc 363
Synonym	More Synonyms

Description	JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
References	[1]. Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. [2]. Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor

References

[1]. Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282.

[2]. Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132.

Density	1.6±0.1 g/cm3
Molecular Formula	C₆₉H₉₁N₁₉O₁₆S₂
Molecular Weight	1506.708
Exact Mass	1505.633301
PSA	603.20000
LogP	-3.67
Index of Refraction	1.731
Storage condition	-20°C

1-{[(4R,10S,13S,16R,19S,22S)-13-(3-Carbamimidamidopropyl)-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,1 ;4,17,20,23-heptaazacyclohexacosan-4-yl]carbonyl}-L-prolyl-L-prolyl-L-lysyl-L-α-asparagine

L-α-Asparagine, 1-[[(4R,10S,13S,16R,19S,22S)-13-[3-[(aminoiminomethyl)amino]propyl]-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthalenylmethyl)-6,9,12,15,18, 21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacos-4-yl]carbonyl]-L-prolyl-L-prolyl-L-lysyl-

DC Chemicals Limited
China
Product Name: JKC363
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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