JKC 363 TFA
Modify Date: 2024-01-08 10:32:57
JKC 363 TFA structure
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Common Name | JKC 363 TFA | ||
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| CAS Number | 436083-30-6 | Molecular Weight | 1506.708 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C69H91N19O16S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JKC 363 TFAJKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2]. |
| Name | jkc 363 |
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| Synonym | More Synonyms |
| Description | JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C69H91N19O16S2 |
| Molecular Weight | 1506.708 |
| Exact Mass | 1505.633301 |
| PSA | 603.20000 |
| LogP | -3.67 |
| Index of Refraction | 1.731 |
| Storage condition | -20°C |
| 1-{[(4R,10S,13S,16R,19S,22S)-13-(3-Carbamimidamidopropyl)-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,1 ;4,17,20,23-heptaazacyclohexacosan-4-yl]carbonyl}-L-prolyl-L-prolyl-L-lysyl-L-α-asparagine |
| L-α-Asparagine, 1-[[(4R,10S,13S,16R,19S,22S)-13-[3-[(aminoiminomethyl)amino]propyl]-22-(2-carboxyethyl)-19-(1H-imidazol-4-ylmethyl)-10-(1H-indol-3-ylmethyl)-16-(2-naphthalenylmethyl)-6,9,12,15,18, 21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptaazacyclohexacos-4-yl]carbonyl]-L-prolyl-L-prolyl-L-lysyl- |