- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: D-Ala2] Deltorphin I
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
122752-15-2
122752-15-2 structure
- Name: Deltorphin I TFA
- Chemical Name: (3S)-3-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
- CAS Number: 122752-15-2
- Molecular Formula: C37H52N8O10
- Molecular Weight: 768.85600
- Catalog: Peptides
- Create Date: 2018-12-27 17:56:15
- Modify Date: 2024-01-02 17:40:39
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Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.
| Name | (3S)-3-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid |
|---|---|
| Synonyms |
H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2
deltorphin I Deltorphin C Tyr-D-Ala-Phe-Asp-Val-Val-Cly-NH2 |
| Description | Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity. |
|---|---|
| Related Catalog | |
| Target |
δ-opioid receptor[1] |
| In Vivo | Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent[1]. |
| Animal Admin | Mice[1] Male Kunming mice (20.0±1.0 g) are used. In order to investigate the chronic effect of Melatonin on opioid receptor agonist analgesia, 18, 17, 16 and 21 mice are treated with Melatonin (0, 0.5, 1 and 2.5 mg/kg, respectively) twice daily for 4 days. On the 5th day, 8, 8, 8 and 9 mice are administered with Endomorphin-1 18 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively), while 10, 9, 8 and 12 mice are administered with Deltorphin I 20 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively). Subsequently tail-flick latency is measured at 10 min interval within 60 min[1]. |
| References |
| Density | 1.284g/cm3 |
|---|---|
| Boiling Point | 1242.4ºC at 760mmHg |
| Molecular Formula | C37H52N8O10 |
| Molecular Weight | 768.85600 |
| Flash Point | 705.2ºC |
| Exact Mass | 768.38100 |
| PSA | 301.24000 |
| LogP | 2.08280 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.578 |
| Storage condition | 2-8℃ |
| Precursor 6 | |
|---|---|
| DownStream 0 | |
