SSR 149415

Modify Date: 2025-08-25 14:07:49

SSR 149415 structure	Common Name	SSR 149415
	CAS Number	439687-69-1	Molecular Weight	630.11
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₂ClN₃O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SSR 149415

Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b Receptor antagonist (Ki: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Nelivaptan inhibits arginine vasopressin (AVP)-induced Ca2+ increase and corticotropin secretion. Nelivaptan can be used for research of stress and anxiety[1].

Name	(2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide
Synonym	More Synonyms

Description	Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b Receptor antagonist (Ki: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Nelivaptan inhibits arginine vasopressin (AVP)-induced Ca2+ increase and corticotropin secretion. Nelivaptan can be used for research of stress and anxiety[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Neurological Disease
References	[1]. Claudine Serradeil-Le Gal, et al. Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist. Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1122-1130. [2]. Serradeil-Le Gal C, et al. An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 2005 Spring;11(1):53-68.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

Research Areas >> Neurological Disease

References

[1]. Claudine Serradeil-Le Gal, et al. Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist. Journal of Pharmacology and Experimental Therapeutics March 2002, 300 (3) 1122-1130.

[2]. Serradeil-Le Gal C, et al. An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 2005 Spring;11(1):53-68.

Molecular Formula	C₃₀H₃₂ClN₃O₈S
Molecular Weight	630.11
Exact Mass	629.16000
PSA	134.30000
LogP	3.95200
InChIKey	NJXZWIIMWNEOGJ-WEWKHQNJSA-N
SMILES	COc1ccc(S(=O)(=O)N2C(=O)C(c3ccccc3OC)(N3CC(O)CC3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1

Nelivaptan

Nelivaptan [INN]

UNII-3TY57MQ4OA

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SSR 149415
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Nelivaptan
Price: $1780.0/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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SSR 149415

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SSR 149415 Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.