BTA-1

Modify Date: 2024-01-02 10:57:15

BTA-1 structure	Common Name	BTA-1
	CAS Number	439858-28-3	Molecular Weight	240.32300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₂N₂S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of BTA-1

BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has high affinity for Aβ fibrils and shows very good brain entry and clearance[1].

Name	4-(1,3-benzothiazol-2-yl)-N-methylaniline
Synonym	More Synonyms

Description	BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has high affinity for Aβ fibrils and shows very good brain entry and clearance[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Klunk WE, et al. The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci. 2003;23(6):2086-2092.

Molecular Formula	C₁₄H₁₂N₂S
Molecular Weight	240.32300
Exact Mass	240.07200
PSA	53.16000
LogP	4.07800
Storage condition	2-8℃

BTA-1 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
HS Code	2934200090

HS Code	2934200090
Summary	2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.

Nat. Commun. 6 , 6176, (2015)

In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier w...

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

J. Neurosci. 23 , 2086-2092, (2003)

2-(4'-methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Abeta fibrils and shows very good brain entry and clearance. In this study, we asked...

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Bioorg. Med. Chem. Lett. 12 , 295-298, (2002)

The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control ...

2-(4'-Methylaminophenyl)benzothiazole

BTA-1

Benzo-Thiazole-Aniline-1-Methyl