Besifovir

Modify Date: 2024-01-15 00:25:46

Besifovir structure	Common Name	Besifovir
	CAS Number	441785-25-7	Molecular Weight	299.223
	Density	1.9±0.1 g/cm3	Boiling Point	668.4±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₄N₅O₄P	Melting Point	N/A
	MSDS	N/A	Flash Point	358.0±34.3 °C

Use of Besifovir

Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].

Name	[1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid
Synonym	More Synonyms

Description	Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
References	[1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. [2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

Description

Besifovir (LB80331), a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV) [1][2].

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

References

[1]. Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64.

[2]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

Density	1.9±0.1 g/cm3
Boiling Point	668.4±65.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₄N₅O₄P
Molecular Weight	299.223
Flash Point	358.0±34.3 °C
Exact Mass	299.078339
PSA	146.19000
LogP	-2.56
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.826

HS Code	2933990090

diisopropyl ({1...

CAS#:693788-86-2

~90%

Besifovir

CAS#:441785-25-7

Literature: Choi, Jong-Ryoo; Cho, Dong-Gyu; Roh, Kee Y.; Hwang, Jae-Taeg; Ahn, Sinbyoung; Jang, Hyun S.; Cho, Woo-Young; Kim, Kyong W.; Cho, Young-Gyo; Kim, Jeongmin; Kim, Yong-Zu Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2864 - 2869

diisopropyl {[1...

CAS#:441784-85-6

Besifovir

CAS#:441785-25-7

[[[1-[[(Methyls...

CAS#:441784-86-7

Besifovir

CAS#:441785-25-7

N/A

CAS#:441784-88-9

Besifovir

CAS#:441785-25-7

diisopropyl (1-...

CAS#:441784-84-5

Besifovir

CAS#:441785-25-7

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

UNII-4PLG22CQUU

[({1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]phosphonic acid

Besifovir

Phosphonic acid, [[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ((1-((2-AMINO-9H-PURIN-9-YL)METHYL)CYCLOPROPOXY)METHYL)PHOSPHONIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥1870/10 mM * 1 mL in DMSO

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Besifovir

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