ASP 9853
Modify Date: 2024-01-17 19:36:40
ASP 9853 structure
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Common Name | ASP 9853 | ||
|---|---|---|---|---|
| CAS Number | 442198-67-6 | Molecular Weight | 617.019 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 877.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C29H28ClF3N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 484.6±34.3 °C | |
Use of ASP 9853A potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS; reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure; also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe. Blood Cancer Phase 1 Discontinued |
| Name | FK-330 |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS; reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure; also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe. Blood Cancer Phase 1 Discontinued |
|---|---|
| References | References 1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58. 2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6. View Related Products by Target Nitric Oxide Synthase (NOS) Blood Cancer |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 877.6±65.0 °C at 760 mmHg |
| Molecular Formula | C29H28ClF3N6O4 |
| Molecular Weight | 617.019 |
| Flash Point | 484.6±34.3 °C |
| Exact Mass | 616.181274 |
| LogP | 3.79 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.594 |
| FK-330 |
| N2-[(2E)-3-(4-Chlorophenyl)-2-propenoyl]-N-[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]-3-(2-pyridinyl)-L-alaninamide |
| K47C68D94B |
| 2-Pyridinepropanamide, α-[[(2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl]amino]-N-[2-oxo-2-[4-[[6-(trifluoromethyl)-4-pyrimidinyl]oxy]-1-piperidinyl]ethyl]-, (αS)- |