Ligustilide

Modify Date: 2024-01-02 18:23:15

Ligustilide structure	Common Name	Ligustilide
	CAS Number	4431-01-0	Molecular Weight	190.238
	Density	1.1±0.1 g/cm3	Boiling Point	377.9±11.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₄O₂	Melting Point	297-298ºC
	MSDS	Chinese USA	Flash Point	158.6±16.7 °C
	Symbol	GHS06	Signal Word	Danger

Use of Ligustilide

Ligustilide is an effective constituent extracted from Angelica sinensis.IC50 value:Target:In vitro: To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide [1].In vivo:

Name	Ligustilide
Synonym	More Synonyms

Description	Ligustilide is an effective constituent extracted from Angelica sinensis.IC50 value:Target:In vitro: To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide [1].In vivo:
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others Natural Products >> Others
References	[1]. Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50(2):162-8. [2]. Du H, et al. A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction. Se Pu. 2015 May;33(5):530-4.

Description

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Research Areas >> Others

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References

[1]. Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50(2):162-8.

[2]. Du H, et al. A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction. Se Pu. 2015 May;33(5):530-4.

Density	1.1±0.1 g/cm3
Boiling Point	377.9±11.0 °C at 760 mmHg
Melting Point	297-298ºC
Molecular Formula	C₁₂H₁₄O₂
Molecular Weight	190.238
Flash Point	158.6±16.7 °C
Exact Mass	190.099380
PSA	26.30000
LogP	2.63
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.545

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	Xi
Risk Phrases	22/23
Safety Phrases	24/25
RIDADR	2810
RTECS	NP6810000

3-BUTYLIDENE-4,5-DIHYDROPHTHALIDE

3-BUTYLIDEN-4,5-DIHYDRO-3H-ISOBENZOFURAN-1-ONE

Ligustilide

3-Butyliden-1-oxo-1.3.4.5-tetrahydro-isobenzofuran

Angelica Extract Powder

LIGUSTILIDE,Z

cis-ligustilide

Ligustilide, (Z)-

1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)-

Z-LIGUSTILIDE

(3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one

3-butylidene-4,5-dihydro-3H-isobenzofuran-1-one

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ligustilide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Ligustilide
Price: ￥800.0/5mg
Purity: 93.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ligustilide
Price: ￥738.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Ligustilide
Price: $400.0/100mg $700.0/250mg $1400.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Ligustilide
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: $238/10mM*1mLinDMSO

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Ligustilide

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