phosphoric acid,pyridine-3,4-diamine

Modify Date: 2024-01-16 22:07:38

phosphoric acid,pyridine-3,4-diamine structure	Common Name	phosphoric acid,pyridine-3,4-diamine
	CAS Number	446254-47-3	Molecular Weight	207.12400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅H₁₀N₃O₄P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of phosphoric acid,pyridine-3,4-diamine

Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels[1]. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research[1].

Name	phosphoric acid,pyridine-3,4-diamine
Synonym	More Synonyms

Description	Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels[1]. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vivo	Amifampridine phosphate treatment (Intravenous injection; 2.5 mg/kg; once) shows 1 hour plasma half-life[2]. Amifampridine phosphate treatment (Oral administration; 10 mg/kg; once) shows plasma concentrations spike[2]. Animal Model: Mice[2] Dosage: 2.5 mg/kg Administration: Intravenous injection; 2.5 mg/kg; once Result: Had a plasma half-life of about 1 hour. Animal Model: Mice[2] Dosage: 10 mg/kg Administration: Oral administration; 10 mg/kg; once Result: Exhibited a rapid spike in plasma concentrations.
References	[1]. Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10(12):1098-107. [2]. T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb). 2016 Mar 18;52(22):4187-90.

Molecular Formula	C₅H₁₀N₃O₄P
Molecular Weight	207.12400
Exact Mass	207.04100
PSA	153.23000

3,4-Diaminopyridine

CAS#:54-96-6

phosphoric acid...

CAS#:446254-47-3

Literature: Guyon, Francois; Pradeau, Dominique; Le Hoang, My Dung; Houri, Jean-Jacques Patent: US2004/106651 A1, 2004 ; Location in patent: Page 3 ;

Precursor 1
CAS#:54-96-6 3,4-Diaminopyridine
DownStream 0

Amifampridine phosphate

3,4-Diaminopyridine phosphate

UNII-8HF8FIN815

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phosphoric acid,pyridine-3,4-diamine

Use of phosphoric acid,pyridine-3,4-diamine

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.