IR415
Modify Date: 2024-09-16 16:24:24
IR415 structure
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Common Name | IR415 | ||
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| CAS Number | 452967-14-5 | Molecular Weight | 296.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H14F2N4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IR415IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner. |
| Name | IR415 |
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| Synonym | More Synonyms |
| Description | IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner. |
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| References | References 1. Ghosh S, et al. J Biol Chem. 2017 Jul 28;292(30):12577-12588. View Related Products by Target HBV |
| Molecular Formula | C13H14F2N4S |
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| Molecular Weight | 296.34 |
| Hazard Codes | Xi |
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| MFCD00238878 |