2-Methylglutaronitrile

Modify Date: 2024-01-01 21:33:14

2-Methylglutaronitrile structure	Common Name	2-Methylglutaronitrile
	CAS Number	4553-62-2	Molecular Weight	108.14100
	Density	0.95 g/mL at 25 °C(lit.)	Boiling Point	269-271 °C(lit.)
	Molecular Formula	C₆H₈N₂	Melting Point	−45 °C(lit.)
	MSDS	Chinese USA	Flash Point	>230 °F
	Symbol	GHS06	Signal Word	Danger

Name	2-Methylglutaronitrile
Synonym	More Synonyms

Density	0.95 g/mL at 25 °C(lit.)
Boiling Point	269-271 °C(lit.)
Melting Point	−45 °C(lit.)
Molecular Formula	C₆H₈N₂
Molecular Weight	108.14100
Flash Point	>230 °F
Exact Mass	108.06900
PSA	47.58000
LogP	1.44986
Index of Refraction	n20/D 1.434(lit.)

2-Methylglutaronitrile MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV8140000

CHEMICAL NAME :: 1,5-Valerodinitrile, 2-methyl-

CAS REGISTRY NUMBER :: 4553-62-2

BEILSTEIN REFERENCE NO. :: 1741955

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: NCYU1&2CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301 + H311-H330
Precautionary Statements	P260-P280-P284-P301 + P310-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S36/37
RIDADR	3276
WGK Germany	3
RTECS	YV8140000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2926909090

Precursor 10
CAS#:25899-50-7 cis-2-Pentenenitrile CAS#:74-90-8 HYDROGEN CYANIDE CAS#:201230-82-2 carbon monoxide CAS#:107-13-1 Acrylonitrile
CAS#:108-93-0 Cyclohexanol CAS#:4635-87-4 pent-3-enenitrile CAS#:75-86-5 Acetone cyanohydrin CAS#:592-51-8 pent-4-enenitrile
CAS#:106-99-0 butadiene CAS#:13284-42-9 2-pentenenitrile
DownStream 9
CAS#:3298-16-6 5-methylpiperid... CAS#:54718-39-7 2,5,6-Trichloro... CAS#:18069-17-5 (2R)-2-Methylpe... CAS#:23886-52-4 4-cyanopentanoi...
CAS#:25899-50-7 cis-2-Pentenenitrile CAS#:26294-98-4 2-Pentenenitrile CAS#:16529-66-1 3-PENTENENITRILE CAS#:20068-02-4 (Z)-2-methyl-2-...
CAS#:30574-97-1 (E)-2-Methyl-2-...

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Inhalation toxicity of methylglutaronitrile in rats.

Drug Chem. Toxicol. 26(2) , 99-115, (2003)

Methylglutaronitrile (MGN) is a high-boiling (263 degrees C) solvent/intermediate used in the fiber industry. Twenty male rats per group were exposed nose-only to condensation aerosol/vapor concentrat...

Synthesis of picolines and other aza-aromatics from arylamines by isomerization-rearrangement and from dinitriles by hydrogenation-cyclization reactions. Prins R.

Catal. Today 37(2) , 103-120, (1997)

Synthesis of ß-picoline from 2-methylglutaronitrile over supported noble metal catalysts II. Influence of operation parameters. Lanini S and Prins R.

Appl. Catal. A Gen. 137(2) , 307-326, (1996)

1,3-Dicyanobutane

MFCD00001875

2-METHYLGLUTARONITRILE

EINECS 224-923-5

2-methylpentanedinitrile