Ethylene Dimethanesulfonate

Modify Date: 2026-07-01 16:28:22

Ethylene Dimethanesulfonate structure	Common Name	Ethylene Dimethanesulfonate
	CAS Number	4672-49-5	Molecular Weight	218.24900
	Density	1.461g/cm3	Boiling Point	448.9ºC at 760 mmHg
	Molecular Formula	C₄H₁₀O₆S₂	Melting Point	35-36℃
	MSDS	N/A	Flash Point	225.3ºC

Use of Ethylene Dimethanesulfonate

Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-methylsulfonyloxyethyl methanesulfonate
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
In Vivo	Ethylene dimethanesulfonate (subcutaneous injection; 75 mg/kg; 7 days) disrupts epididymal function and leads to sperm granuloma formation in rat[1].
References	[1]. Dutta D, et al. Ethylene dimethane sulfonate (EDS) ablation of Leydig cells in adult rat depletes testosterone resulting in epididymal sperm granuloma: Testosterone replacement prevents granuloma formation. Reprod Biol. 2019 Mar;19(1):89-99.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.461g/cm3
Boiling Point	448.9ºC at 760 mmHg
Melting Point	35-36℃
Molecular Formula	C₄H₁₀O₆S₂
Molecular Weight	218.24900
Flash Point	225.3ºC
Exact Mass	217.99200
PSA	103.50000
LogP	1.10040
Index of Refraction	1.47
InChIKey	QSQFARNGNIZGAW-UHFFFAOYSA-N
SMILES	CS(=O)(=O)OCCOS(C)(=O)=O

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KW5540000

CHEMICAL NAME :: Ethylene glycol, dimethanesulfonate

CAS REGISTRY NUMBER :: 4672-49-5

BEILSTEIN REFERENCE NO. :: 1787642

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C4-H10-O6-S2

MOLECULAR WEIGHT :: 218.26

WISWESSER LINE NOTATION :: WS1&O2OSW1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 24,24,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,211,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: 85GUAJ "Antifertility Compounds in the Male and Female," Jackson, H., Springfield, IL, Charles C. Thomas, 1966 Volume(issue)/page/year: -,55,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 153 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,901,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 275 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,901,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 50 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: 15QWAW "Agents Affecting Fertility, a Symposium, 1964," Austin, C.R., and J.S. Perry, eds., Boston, Little, Brown & Co., 1965 Volume(issue)/page/year: -,62,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 75 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 71,393,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 118,709,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 75 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: IJANDP International Journal of Andrology. (Scriptor Publisher ApS, 15 Gasvaerksvej, DK-1656 Copenhagen V, Denmark) V.1- 1978- Volume(issue)/page/year: 10,625,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 mg/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 82,381,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

REFERENCE :: REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,497,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 75 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 1,523,1973

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Ethylene glycol

CAS#:107-21-1

Methanesulfonyl...

CAS#:124-63-0

~95%

Ethylene Dimeth...

CAS#:4672-49-5

Learn More

Literature: Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315

ETHYLENE OXIDE

CAS#:75-21-8

Methanesulfonyl...

CAS#:124-63-0

Ethylene Dimeth...

CAS#:4672-49-5

Learn More

Literature: Klamann,D. et al. Justus Liebigs Annalen der Chemie, 1967 , vol. 710, p. 71 - 76

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:107-21-1 Ethylene glycol CAS#:124-63-0 Methanesulfonyl... CAS#:75-21-8 ETHYLENE OXIDE
DownStream 5
CAS#:14262-60-3 Dibenzo-15-crow... CAS#:34074-28-7 4,4’-Ethanediyl... CAS#:14262-61-4 [2,4]-Dibenzo-1... CAS#:553-45-7 1-methoxy-2-[2-...
CAS#:52118-10-2 2-[2-(2-formylp...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Ethylene bis(methanesulfonate)

1,2-Bis(mesyloxy)ethane

ethan-1,2-diyl Dimethanesulfonate

ethylene di(methanesulfonate)

ethyl 1,2-dimethanesulfonate

DMSE

Ethylene Dimethanesulphonate

1,2-bis(methylsulfonyloxy)ethane

Ethylene methanesulfonate

1,2-Ethanediol dimethanesulfonate

ETHYLENE GLYCOL,DIMETHANESULFONATE

Dimethylene dimethanesulfonate

diethylene glycol dimethanesulfonate

Ethane 1,2-dimethanesulfonate

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of 2-methylsulfonyloxyethyl methanesulfonate?

A: Boiling point of 2-methylsulfonyloxyethyl methanesulfonate is 448.9ºC at 760 mmHg.

Q: What are the upstream materials of 2-methylsulfonyloxyethyl methanesulfonate?

A: Related upstream materials(CAS) of 2-methylsulfonyloxyethyl methanesulfonate: 107-21-1;124-63-0;75-21-8.

Q: What is the CAS number of 2-methylsulfonyloxyethyl methanesulfonate?

A: CAS number of 2-methylsulfonyloxyethyl methanesulfonate is 4672-49-5.

Q: What is the InChIKey of 2-methylsulfonyloxyethyl methanesulfonate?

A: InChIKey of 2-methylsulfonyloxyethyl methanesulfonate is QSQFARNGNIZGAW-UHFFFAOYSA-N.

Q: What English synonyms does 2-methylsulfonyloxyethyl methanesulfonate have?

A: English synonyms of 2-methylsulfonyloxyethyl methanesulfonate: Ethylene bis(methanesulfonate), 1,2-Bis(mesyloxy)ethane, ethan-1,2-diyl Dimethanesulfonate, ethylene di(methanesulfonate), ethyl 1,2-dimethanesulfonate, DMSE, Ethylene Dimethanesulphonate, 1,2-bis(methylsulfonyloxy)ethane, Ethylene methanesulfonate, 1,2-Ethanediol dimethanesulfonate, ETHYLENE GLYCOL,DIMETHANESULFONATE, Dimethylene dimethanesulfonate, diethylene glycol dimethanesulfonate, Ethane 1,2-dimethanesulfonate.

Q: What is the melting point of 2-methylsulfonyloxyethyl methanesulfonate?

A: Melting point of 2-methylsulfonyloxyethyl methanesulfonate is 35-36℃.

Q: What are the uses of 2-methylsulfonyloxyethyl methanesulfonate?

A: Main uses of 2-methylsulfonyloxyethyl methanesulfonate: Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs[1].

Q: What is the molecular formula of 2-methylsulfonyloxyethyl methanesulfonate?

A: Molecular formula of 2-methylsulfonyloxyethyl methanesulfonate is C4H10O6S2.

Q: What is the LogP of 2-methylsulfonyloxyethyl methanesulfonate?

A: LogP of 2-methylsulfonyloxyethyl methanesulfonate is 1.10040.

Q: What is the SMILES notation of 2-methylsulfonyloxyethyl methanesulfonate?

A: SMILES notation of 2-methylsulfonyloxyethyl methanesulfonate is CS(=O)(=O)OCCOS(C)(=O)=O.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ethylene Dimethanesulfonate
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethylene dimethanesulfonate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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