Carbenicillin

Modify Date: 2025-08-31 17:15:35

Carbenicillin structure	Common Name	Carbenicillin
	CAS Number	4697-36-3	Molecular Weight	378.40000
	Density	1.53g/cm3	Boiling Point	737.8ºC at 760mmHg
	Molecular Formula	C₁₇H₁₈N₂O₆S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	400ºC

Use of Carbenicillin

Carbenicillin is broad-spectrum semisynthetic penicillin derivative used parenterally.Target: AntibacterialCarbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes [1]. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets [2].

Name	carbenicillin
Synonym	More Synonyms

Description	Carbenicillin is broad-spectrum semisynthetic penicillin derivative used parenterally.Target: AntibacterialCarbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes [1]. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Moller, N.E., et al., Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy, 1980. 35(2): p. 135-8. [2]. Silva, J.d. and S. Fukai, The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth. J. Appl. Hort, 2001. 3(1): p. 3-12.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

References

[1]. Moller, N.E., et al., Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy, 1980. 35(2): p. 135-8.

[2]. Silva, J.d. and S. Fukai, The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth. J. Appl. Hort, 2001. 3(1): p. 3-12.

Density	1.53g/cm3
Boiling Point	737.8ºC at 760mmHg
Molecular Formula	C₁₇H₁₈N₂O₆S
Molecular Weight	378.40000
Flash Point	400ºC
Exact Mass	378.08900
PSA	149.31000
LogP	0.81530
Index of Refraction	1.675
InChIKey	FPPNZSSZRUTDAP-UWFZAAFLSA-N
SMILES	CC1(C)SC2C(NC(=O)C(C(=O)O)c3ccccc3)C(=O)N2C1C(=O)O
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON9104700

CHEMICAL NAME :: Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3 .2.0)hept-6-yl)-2- phenyl-

CAS REGISTRY NUMBER :: 4697-36-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H18-N2-O6-S

MOLECULAR WEIGHT :: 378.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2363 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 280 mg/L

REFERENCE :: HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 3,173,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3591 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 10079 (estimated) No. of Female Employees: 8399 (estimated)

Hazard Codes	Xn
Risk Phrases	R10
Safety Phrases	36/37
RIDADR	UN 1170 3/PG 3
WGK Germany	2

Name: Tested for inhibition of visible growth of Proteus mirabilis
Source: ChEMBL
Target: Proteus mirabilis
External Id: CHEMBL768999

Name: Antibacterial activity against Escherichia coli NKE160 harboring deletion mutation in...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267883

Name: Antibacterial activity against Escherichia coli NKE161 harboring deletion mutation in...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267884

Name: Antibacterial activity against Escherichia coli NKE1369 harboring deletion mutation i...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267893

Name: Antibacterial activity against Escherichia coli NKE126 harboring deletion mutation in...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267885

Name: Antibacterial activity against Escherichia coli NKE156 harboring deletion mutation in...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267886

Name: Antibacterial activity against Escherichia coli NKE157 harboring deletion mutation in...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267887

Name: Antibacterial activity against Escherichia coli NKE1365 harboring deletion mutation i...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267888

Name: Antibacterial activity against Escherichia coli NKE1366 harboring deletion mutation i...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267889

Name: Antibacterial activity against Escherichia coli NKE1367 harboring deletion mutation i...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1267890

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Carboxybenzylpenicillin

(2S,5R,6R)-6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

CBPC

Carbenicilline

Geopen

Carbenicilina

Pyopen

Carboxybenzylpenicillin acid

Carbenicillinum

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Carbenicillin

Use of Carbenicillin

Names

Carbenicillin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

CarbenicillinBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.