Dehydrocostus lactone
Modify Date: 2026-07-01 15:04:49
Dehydrocostus lactone structure
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Common Name | Dehydrocostus lactone | ||
|---|---|---|---|---|
| CAS Number | 477-43-0 | Molecular Weight | 230.302 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 383.7±42.0 °C at 760 mmHg | |
| Molecular Formula | C15H18O2 | Melting Point | 59 °C | |
| MSDS | N/A | Flash Point | 161.2±25.3 °C | |
Use of Dehydrocostus lactoneDehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa.IC50 value:Target:In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression.In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3]. |
| Name | dehydrocostus lactone |
|---|---|
| Synonym | More Synonyms |
| Description | Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa.IC50 value:Target:In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression.In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3]. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 383.7±42.0 °C at 760 mmHg |
| Melting Point | 59 °C |
| Molecular Formula | C15H18O2 |
| Molecular Weight | 230.302 |
| Flash Point | 161.2±25.3 °C |
| Exact Mass | 230.130676 |
| PSA | 26.30000 |
| LogP | 3.40 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | NETSQGRTUNRXEO-XUXIUFHCSA-N |
| SMILES | C=C1C(=O)OC2C1CCC(=C)C1CCC(=C)C12 |
| Storage condition | room temp |
| Hazard Codes | Xn |
|---|---|
| Risk Phrases | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36-S36/37/39 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 29089000 |
| HS Code | 29089000 |
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| DEHYDROCOSTUNOLIDE |
| Costus lactone,dehydro |
| dehydrocustoslactone |
| (3aS,6aR,9aR,9bS)-3,6,9-trimethylidenedecahydroazuleno[4,5-b]furan-2(3H)-one |
| MFCD00210277 |
| (3aS,6aR,9aR,9bS)-3,6,9-Tris(methylene)decahydroazuleno[4,5-b]furan-2(3H)-one |
| EPILIGULYL OXIDE |
| Dehydrocostus lactone |