Obtusifolin
Obtusifolin structure
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Common Name | Obtusifolin | ||
|---|---|---|---|---|
| CAS Number | 477-85-0 | Molecular Weight | 284.263 | |
| Density | 1.448±0.06 g/cm3 | Boiling Point | 528.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O5 | Melting Point | 242-243ºC | |
| MSDS | N/A | Flash Point | 202.2±23.6 °C | |
Use of ObtusifolinObtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
Summary: Obtusifolin, also known as obtusifolin, is a chemical named 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione with CAS number 477-85-0, having a molecular formula of C16H12O5 and a molecular weight of 284.263. It appears as a powder, with a melting point of 242-243℃. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.448±0.06 g/cm3 |
|---|---|
| Boiling Point | 528.0±50.0 °C at 760 mmHg |
| Melting Point | 242-243ºC |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.263 |
| Flash Point | 202.2±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 83.83000 |
| LogP | 4.18 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.678 |
| InChIKey | NYRXUBDGDSRBGB-UHFFFAOYSA-N |
| SMILES | COc1c(O)c(C)cc2c1C(=O)c1c(O)cccc1C2=O |
| Storage condition | -20℃ |
| Water Solubility | Insuluble (2.6E-3 g/L) (25 ºC) |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~0%
Obtusifolin CAS#:477-85-0
Learn More
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| Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
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~%
Obtusifolin CAS#:477-85-0 |
| Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
|
~98%
Obtusifolin CAS#:477-85-0 |
| Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
|
~60%
Obtusifolin CAS#:477-85-0
Learn More
|
| Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
|
~%
Obtusifolin CAS#:477-85-0 |
| Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 |
|
~%
Obtusifolin CAS#:477-85-0 |
| Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
|
~%
Obtusifolin CAS#:477-85-0 |
| Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
|
~%
Obtusifolin CAS#:477-85-0 |
| Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176 |
|
~%
Obtusifolin CAS#:477-85-0 |
| Literature: Krohn, Carsten; Khanbabaee, Karamali Liebigs Annalen der Chemie, 1993 , # 8 p. 905 - 910 |
![(E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene structure](https://image.chemsrc.com/caspic/307/72476-03-0.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 2 | |
CAS#:82868-99-3This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl |
| 2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone |
| 2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon |
| obtusifoline |
| Obtusifolin (anthraquinone) |
| 1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone |
| 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone |
| Obtusifolin |
| 2,8-dihydroxy-1-methoxy-3-methylanhraquinone |
| 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Related downstream products(CAS) of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione: 82868-99-3;58322-78-4. |
| Q: What English synonyms does 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione have? |
| A: English synonyms of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione: Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl, 2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone, 2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon, obtusifoline, Obtusifolin (anthraquinone), 1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone, 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone, Obtusifolin, 2,8-dihydroxy-1-methoxy-3-methylanhraquinone, 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione. |
| Q: What is the melting point of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Melting point of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione is 242-243ºC. |
| Q: What is the LogP of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: LogP of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione is 4.18. |
| Q: What is the molecular formula of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Molecular formula of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione is C16H12O5. |
| Q: What is the molecular weight of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Molecular weight of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione is 284.263. |
| Q: What is the English name of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: The English name of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione is 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione. |
| Q: What is the polar surface area (PSA) of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Polar surface area (PSA) of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione is 83.83000. |
| Q: What are the storage conditions for 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Storage conditions for 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione: -20℃. |
| Q: What are the uses of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione? |
| A: Main uses of 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione: Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |