Juglone

Modify Date: 2026-07-03 10:52:44

Juglone structure	Common Name	Juglone
	CAS Number	481-39-0	Molecular Weight	174.153
	Density	1.4±0.1 g/cm3	Boiling Point	385.8±42.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₆O₃	Melting Point	161-163 °C(lit.)
	MSDS	Chinese USA	Flash Point	201.3±24.4 °C
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of Juglone

Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	juglone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. J. Johnson Inbaraj, et al. Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes.Chem. Res. Toxicol. 2004, 17, 1, 55-62

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.4±0.1 g/cm3
Boiling Point	385.8±42.0 °C at 760 mmHg
Melting Point	161-163 °C(lit.)
Molecular Formula	C₁₀H₆O₃
Molecular Weight	174.153
Flash Point	201.3±24.4 °C
Exact Mass	174.031693
PSA	54.37000
LogP	1.86
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.662
InChIKey	KQPYUDDGWXQXHS-UHFFFAOYSA-N
SMILES	O=C1C=CC(=O)c2c(O)cccc21
Storage condition	Refrigerator (+4°C)
Water Solubility	SOLUBLE IN HOT WATER

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Juglone MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5775000

CHEMICAL NAME :: 1,4-Naphthalenedione, 5-hydroxy-

CAS REGISTRY NUMBER :: 481-39-0

BEILSTEIN REFERENCE NO. :: 1909764

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H6-O3

MOLECULAR WEIGHT :: 174.16

WISWESSER LINE NOTATION :: L66 BV EVJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 394 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 10 mg/kg

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,583,1967

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335-H400
Precautionary Statements	P261-P273-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S22-S26-S36/37/39-S45-S37/39-S28A
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	QJ5775000
Packaging Group	III
Hazard Class	6.1
HS Code	2914690090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 7
CAS#:83-56-7 1,5-Dihydroxyna... CAS#:496-64-0 3-Hydroxy-2H-Py... CAS#:106-51-4 1,4-Benzoquinone CAS#:569-42-6 1,8-Naphthalenediol
CAS#:5196-28-1 5-(acetyloxy)-1... CAS#:115031-12-4 2-Morpholinomet... CAS#:481-40-3 naphthalene-1,4...
DownStream 10
CAS#:481-72-1 Aloeemodin CAS#:477-85-0 Obtusifolin CAS#:481-74-3 Chrysophanic acid CAS#:67116-22-7 8-hydroxy-1-met...
CAS#:18855-92-0 2-chloro-8-hydr... CAS#:18713-45-6 (8-acetyloxy-3-... CAS#:481-42-5 Plumbagin CAS#:14777-17-4 5-hydroxy-3-met...
CAS#:80596-51-6 2,3-dimethyl-5-... CAS#:129-43-1 1-HYDROXYANTHRA...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.

Oncotarget 6 , 16488-506, (2015)

Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor su...

Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III.

J. Enzyme Inhib. Med. Chem. 30 , 420-9, (2015)

An HPLC-size exclusion method was developed as an assay method to evaluate the binding of tested compounds with carbonic anhydrase III (CAIII) enzyme. Inhibition of CAIII by a group of benzoic acid an...

Determination of the Juglone Content of Juglans regia Leaves by GC/MS.

Nat. Prod. Commun. 10 , 1239-42, (2015)

The constituents of walnut (Juglans regia L.) leaves are represented by tannins, phenolics, and naphthoquinones, the characteristic compound being juglone. The content of juglone in the methanolic ext...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Nucin

Juglone

EINECS 207-567-5

5-Hydroxy-1,4-naphthalenedione

C.I. Natural Brown 7

5-hydroxynaphthalene-1,4-dione

Regianin

CI 75500

5-hydroxy-1,4-dihydronaphthalene-1,4-dione

5-Hydroxy-1,4-naphthochinone

5-HNQ

5-Hydroxy-p-naphthoquinone

MFCD00001684

5-Hydroxy-1,4-naphthoquinone

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of juglone?

A: The English name of juglone is juglone.

Q: What is the SMILES notation of juglone?

A: SMILES notation of juglone is O=C1C=CC(=O)c2c(O)cccc21.

Q: What is the polar surface area (PSA) of juglone?

A: Polar surface area (PSA) of juglone is 54.37000.

Q: How is the water solubility of juglone?

A: Water solubility of juglone: SOLUBLE IN HOT WATER.

Q: What is the CAS number of juglone?

A: CAS number of juglone is 481-39-0.

Q: What is the molecular weight of juglone?

A: Molecular weight of juglone is 174.153.

Q: What is the LogP of juglone?

A: LogP of juglone is 1.86.

Q: What are the downstream products of juglone?

A: Related downstream products(CAS) of juglone: 481-72-1;477-85-0;481-74-3;67116-22-7;18855-92-0;18713-45-6;481-42-5;14777-17-4;80596-51-6;129-43-1.

Q: What are the upstream materials of juglone?

A: Related upstream materials(CAS) of juglone: 83-56-7;496-64-0;106-51-4;569-42-6;5196-28-1;115031-12-4;481-40-3.

Q: What is the melting point of juglone?

A: Melting point of juglone is 161-163 °C(lit.).

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

naturewill

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Juglone
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China
Product Name: Juglone
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naturewill
China
Product Name: Juglone
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
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Price: ￥500/5 mg

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Juglone

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