Lucidin
Lucidin structure
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Common Name | Lucidin | ||
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| CAS Number | 478-08-0 | Molecular Weight | 270.237 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 585.0±29.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O5 | Melting Point | 330ºC | |
| MSDS | N/A | Flash Point | 321.6±20.8 °C | |
Use of LucidinLucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.IC50 Value:Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3'-phosphate with lucidin [2].in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2].Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2].Clinical trial: |
Summary: 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione (Lucidin), Chinese name: 1,3-二羟基-2-(羟基甲基)蒽醌, CAS number: 478-08-0, molecular formula: C15H10O5, molecular weight: 270.237. The melting point is 330ºC, boiling point is 585.0±29.0 °C at 760 mmHg, and density is 1.6±0.1 g/cm3. Storage condition: -20°C. Lucidin (NSC 30546) is a natural component of Chinese herb and can induce mutations in bacteria and mammalian cells. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.IC50 Value:Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3'-phosphate with lucidin [2].in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2].Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2].Clinical trial: |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 585.0±29.0 °C at 760 mmHg |
| Melting Point | 330ºC |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.237 |
| Flash Point | 321.6±20.8 °C |
| Exact Mass | 270.052826 |
| PSA | 94.83000 |
| LogP | 2.79 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.746 |
| InChIKey | AMIDUPFSOUCLQB-UHFFFAOYSA-N |
| SMILES | O=C1c2ccccc2C(=O)c2c1cc(O)c(CO)c2O |
| Storage condition | -20°C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Lucidin CAS#:478-08-0 |
| Literature: Jegorov, Alexandr; Cvak, Ladislav; Cejka, Jan; Kratochvil, Bohumil; Sedmera, Petr; Havlicek, Vladimir Journal of Chemical Crystallography, 2005 , vol. 35, # 8 p. 621 - 627 |
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Lucidin CAS#:478-08-0 |
| Literature: Tosa, Hideki; Iinuma, Munekazu; Asai, Fujio; Tanaka, Toshiyuki; Nozaki, Hiroshi; Ikeda, Shougo; Tsutsui, Ken; Tsutsui, Kimiko; Yamada, Masashi; Fujimori, Shiho Biological and Pharmaceutical Bulletin, 1998 , vol. 21, # 6 p. 641 - 642 |
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Lucidin CAS#:478-08-0 |
| Literature: Joshi et al. Journal of Scientific and Industrial Research, 1955 , vol. 14 B, p. 87,92 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
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| DownStream 7 | |
CAS#:477-84-9
CAS#:61434-48-8
CAS#:184916-38-9
CAS#:3736-59-2
CAS#:477-83-8
CAS#:478-06-8
CAS#:61434-47-7This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Henine |
| 1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone |
| 1,3-dihydroxy-2-hydroxymethyl-9,10-anthracenedione |
| 1,3-Dihydroxy-2-(hydroxymethyl)-9,10-anthraquinone |
| 1,3-dihydroxy-2-hydroxymethyl-anthraquinone |
| Lucidin (quinone) |
| 2-carbinol-1,3-dihydroxyanthraquinone |
| Lucidin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: Related downstream products(CAS) of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione: 477-84-9;61434-48-8;184916-38-9;3736-59-2;477-83-8;478-06-8;61434-47-7. |
| Q: What is the English name of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: The English name of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione. |
| Q: What English synonyms does 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione have? |
| A: English synonyms of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione: Henine, 1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone, 1,3-dihydroxy-2-hydroxymethyl-9,10-anthracenedione, 1,3-Dihydroxy-2-(hydroxymethyl)-9,10-anthraquinone, 1,3-dihydroxy-2-hydroxymethyl-anthraquinone, Lucidin (quinone), 2-carbinol-1,3-dihydroxyanthraquinone, Lucidin. |
| Q: What are the storage conditions for 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: Storage conditions for 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione: -20°C. |
| Q: What is the boiling point of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: Boiling point of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is 585.0±29.0 °C at 760 mmHg. |
| Q: What is the LogP of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: LogP of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is 2.79. |
| Q: What is the InChIKey of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: InChIKey of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is AMIDUPFSOUCLQB-UHFFFAOYSA-N. |
| Q: What is the molecular weight of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: Molecular weight of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is 270.237. |
| Q: What is the melting point of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: Melting point of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is 330ºC. |
| Q: What is the SMILES notation of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione? |
| A: SMILES notation of 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione is O=C1c2ccccc2C(=O)c2c1cc(O)c(CO)c2O. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |