6-Hydroxy-5,7-dimethoxy-2H-chromen-2-one
6-Hydroxy-5,7-dimethoxy-2H-chromen-2-one structure
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Common Name | 6-Hydroxy-5,7-dimethoxy-2H-chromen-2-one | ||
|---|---|---|---|---|
| CAS Number | 486-28-2 | Molecular Weight | 222.194 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 449.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C11H10O5 | Melting Point | 170-172ºC | |
| MSDS | N/A | Flash Point | 182.1±22.2 °C | |
Use of 6-Hydroxy-5,7-dimethoxy-2H-chromen-2-oneFraxinol is isolated from Lobelia chinensis[1]. |
Summary: 6-Hydroxy-5,7-dimethoxychromen-2-one, also known as 6-hydroxy-5,7-dimethoxy-2H-chromen-2-one, with CAS number 486-28-2, has a molecular formula of C11H10O5 and a molecular weight of 222.194. It appears as a powder, with a melting point of 170-172°C and a boiling point of 449.7±45.0 °C at 760 mmHg, and a density of 1.4±0.1 g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-hydroxy-5,7-dimethoxychromen-2-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Fraxinol is isolated from Lobelia chinensis[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 449.7±45.0 °C at 760 mmHg |
| Melting Point | 170-172ºC |
| Molecular Formula | C11H10O5 |
| Molecular Weight | 222.194 |
| Flash Point | 182.1±22.2 °C |
| Exact Mass | 222.052826 |
| PSA | 68.90000 |
| LogP | 0.90 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.588 |
| InChIKey | PBPNOAHYDPHKFH-UHFFFAOYSA-N |
| SMILES | COc1cc2oc(=O)ccc2c(OC)c1O |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~59%
6-Hydroxy-5,7-d... CAS#:486-28-2 |
| Literature: Riveiro, Maria E.; Maes, Dominick; Vazquez, Ramiro; Vermeulen, Monica; Mangelinckx, Sven; Jacobs, Jan; Debenedetti, Silvia; Shayo, Carina; De Kimpe, Norbert; Davio, Carlos Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6547 - 6559 |
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6-Hydroxy-5,7-d... CAS#:486-28-2 |
| Literature: Ishii; Kobayashi; Ishikawa Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3330 - 3333 |
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6-Hydroxy-5,7-d... CAS#:486-28-2 |
| Literature: Ishii; Kobayashi; Ishikawa Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3330 - 3333 |
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6-Hydroxy-5,7-d... CAS#:486-28-2 |
| Literature: xxx Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2000 , vol. 39, # 11 p. 879 - 882 |
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6-Hydroxy-5,7-d... CAS#:486-28-2 |
| Literature: Bhavsar; Desai Indian Journal of Pharmacy, 1951 , vol. 13, p. 200,203 Full Text Show Details Dalvi et al. Journal of the Indian Chemical Society, 1951 , vol. 28, p. 366,369 |
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6-Hydroxy-5,7-d... CAS#:486-28-2 |
| Literature: Tsukamoto; Hisada; Nishibe Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 4069 - 4073 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
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| DownStream 1 | |
CAS#:55085-47-7This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Source: ChEMBL
Target: U-937
External Id: CHEMBL1074620
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Name: Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporatio...
Source: ChEMBL
Target: U-937
External Id: CHEMBL1065376
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6-Hydroxy-5,7-dimethoxy-2H-chromen-2-one |
| 6-hydroxy-5,7-dimethoxy-chromen-2-one |
| 6-hydroxy-5,7-dimethoxycoumarin |
| 5,7-dimethoxy-6-hydroxycoumarin |
| Fraxinol |
| 6-Hydroxy-5,7-dimethoxy-cumarin |
| 2H-1-Benzopyran-2-one,6-hydroxy-5,7-dimethoxy |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does 6-hydroxy-5,7-dimethoxychromen-2-one have? |
| A: English synonyms of 6-hydroxy-5,7-dimethoxychromen-2-one: 6-Hydroxy-5,7-dimethoxy-2H-chromen-2-one, 6-hydroxy-5,7-dimethoxy-chromen-2-one, 6-hydroxy-5,7-dimethoxycoumarin, 5,7-dimethoxy-6-hydroxycoumarin, Fraxinol, 6-Hydroxy-5,7-dimethoxy-cumarin, 2H-1-Benzopyran-2-one,6-hydroxy-5,7-dimethoxy. |
| Q: What is the molecular formula of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: Molecular formula of 6-hydroxy-5,7-dimethoxychromen-2-one is C11H10O5. |
| Q: What is the SMILES notation of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: SMILES notation of 6-hydroxy-5,7-dimethoxychromen-2-one is COc1cc2oc(=O)ccc2c(OC)c1O. |
| Q: What is the molecular weight of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: Molecular weight of 6-hydroxy-5,7-dimethoxychromen-2-one is 222.194. |
| Q: What are the upstream materials of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: Related upstream materials(CAS) of 6-hydroxy-5,7-dimethoxychromen-2-one: 105827-22-3;88140-31-2;88140-32-3;28752-90-1;487-06-9;32451-87-9. |
| Q: What is the melting point of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: Melting point of 6-hydroxy-5,7-dimethoxychromen-2-one is 170-172ºC. |
| Q: What is the boiling point of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: Boiling point of 6-hydroxy-5,7-dimethoxychromen-2-one is 449.7±45.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: Polar surface area (PSA) of 6-hydroxy-5,7-dimethoxychromen-2-one is 68.90000. |
| Q: What is the CAS number of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: CAS number of 6-hydroxy-5,7-dimethoxychromen-2-one is 486-28-2. |
| Q: What is the LogP of 6-hydroxy-5,7-dimethoxychromen-2-one? |
| A: LogP of 6-hydroxy-5,7-dimethoxychromen-2-one is 0.90. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |