ORM-10103

Modify Date: 2024-01-10 09:03:29

ORM-10103 Structure
ORM-10103 structure
Common Name ORM-10103
CAS Number 488847-28-5 Molecular Weight 348.35
Density N/A Boiling Point N/A
Molecular Formula C20H16N2O4 Melting Point N/A
MSDS USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of ORM-10103


ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2].

 Names

Name 5-nitro-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]pyridine

 ORM-10103 Biological Activity

Description ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2].
Related Catalog
Target

IC50: 55 (NCX -80 mV ), 67 nM (NCX 20 mV)[2]

References

[1]. Jost N, et al. ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart. Br J Pharmacol. 2013 Oct;170(4):768-78.

[2]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041.

 Chemical & Physical Properties

Molecular Formula C20H16N2O4
Molecular Weight 348.35
Exact Mass 348.11100
PSA 77.17000
LogP 5.37160
Storage condition 2-8℃

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H413
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII