HOMOQUINOLINIC ACID
HOMOQUINOLINIC ACID structure
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Common Name | HOMOQUINOLINIC ACID | ||
|---|---|---|---|---|
| CAS Number | 490-75-5 | Molecular Weight | 181.15 | |
| Density | 1.477g/cm3 | Boiling Point | 437ºC at 760mmHg | |
| Molecular Formula | C8H7NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 218.1ºC | |
Use of HOMOQUINOLINIC ACIDHomoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2]. |
Summary: HOMOQUINOLINIC ACID, Chinese name: 高奎宁酸, CAS number: 490-75-5, molecular formula: C8H7NO4, molecular weight: 181.15. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 3-(carboxymethyl)pyridine-2-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Homoquinolinic acid (HQA，20 μM) 导致在第V层记录的事件频率显著增加[2]。 Homoquinolinic acid (HQA) 作用于突触前端，增强谷氨酸的释放[2]。 |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.477g/cm3 |
|---|---|
| Boiling Point | 437ºC at 760mmHg |
| Molecular Formula | C8H7NO4 |
| Molecular Weight | 181.15 |
| Flash Point | 218.1ºC |
| Exact Mass | 181.03800 |
| PSA | 87.49000 |
| LogP | 0.40690 |
| Vapour Pressure | 2.07E-08mmHg at 25°C |
| Index of Refraction | 1.607 |
| InChIKey | HQPMJFFEXJELOQ-UHFFFAOYSA-N |
| SMILES | O=C(O)Cc1cccnc1C(=O)O |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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HOMOQUINOLINIC ACID CAS#:490-75-5 |
| Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479 |
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HOMOQUINOLINIC ACID CAS#:490-75-5 |
| Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479 |
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~%
HOMOQUINOLINIC ACID CAS#:490-75-5 |
| Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479 |
![(2-methoxycarbonyl-[3]pyridyl)-acetic acid methyl ester structure](https://image.chemsrc.com/caspic/352/807361-96-2.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
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| DownStream 2 | |
CAS#:501-81-5
CAS#:108-99-6This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: Human GluN2A (Ionotropic glutamate receptors)
Source: IUPHAR-DB
Target: GluN2A (Ionotropic glutamate receptors) [Homo sapiens]
External Id: 456_Human
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2mCherry
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
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Name: Ability to displace [3H]CPP from NMDA receptor in rat brain membrane
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 3A
External Id: CHEMBL748107
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2Venus
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Homoquinolinate |
| Bromocriptine mesylate |
| Homoquinolinic acid |
| Tocris-0197 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: Polar surface area (PSA) of 3-(carboxymethyl)pyridine-2-carboxylic acid is 87.49000. |
| Q: What is the CAS number of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: CAS number of 3-(carboxymethyl)pyridine-2-carboxylic acid is 490-75-5. |
| Q: What is the molecular formula of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: Molecular formula of 3-(carboxymethyl)pyridine-2-carboxylic acid is C8H7NO4. |
| Q: What is the English name of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: The English name of 3-(carboxymethyl)pyridine-2-carboxylic acid is 3-(carboxymethyl)pyridine-2-carboxylic acid. |
| Q: What is the InChIKey of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: InChIKey of 3-(carboxymethyl)pyridine-2-carboxylic acid is HQPMJFFEXJELOQ-UHFFFAOYSA-N. |
| Q: What is the molecular weight of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: Molecular weight of 3-(carboxymethyl)pyridine-2-carboxylic acid is 181.15. |
| Q: What are the uses of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: Main uses of 3-(carboxymethyl)pyridine-2-carboxylic acid: Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2]. |
| Q: What is the boiling point of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: Boiling point of 3-(carboxymethyl)pyridine-2-carboxylic acid is 437ºC at 760mmHg. |
| Q: What English synonyms does 3-(carboxymethyl)pyridine-2-carboxylic acid have? |
| A: English synonyms of 3-(carboxymethyl)pyridine-2-carboxylic acid: Homoquinolinate, Bromocriptine mesylate, Homoquinolinic acid, Tocris-0197. |
| Q: What are the downstream products of 3-(carboxymethyl)pyridine-2-carboxylic acid? |
| A: Related downstream products(CAS) of 3-(carboxymethyl)pyridine-2-carboxylic acid: 501-81-5;108-99-6. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |