HOMOQUINOLINIC ACID

Modify Date: 2025-08-28 00:55:37

HOMOQUINOLINIC ACID Structure
HOMOQUINOLINIC ACID structure
Common Name HOMOQUINOLINIC ACID
CAS Number 490-75-5 Molecular Weight 181.15
Density 1.477g/cm3 Boiling Point 437ºC at 760mmHg
Molecular Formula C8H7NO4 Melting Point N/A
MSDS N/A Flash Point 218.1ºC

 Use of HOMOQUINOLINIC ACID


Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2].

 Names

Name 3-(carboxymethyl)pyridine-2-carboxylic acid
Synonym More Synonyms

 HOMOQUINOLINIC ACID Biological Activity

Description Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2].
Related Catalog
In Vitro Homoquinolinic acid (HQA,20 μM) 导致在第V层记录的事件频率显著增加[2]。 Homoquinolinic acid (HQA) 作用于突触前端,增强谷氨酸的释放[2]。
References

[1]. L P de Carvalho, et al. The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int. 1996 Apr;28(4):445-52.  

[2]. G Woodhall, et al. NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. J Neurophysiol. 2001 Oct;86(4):1644-51.  

 Chemical & Physical Properties

Density 1.477g/cm3
Boiling Point 437ºC at 760mmHg
Molecular Formula C8H7NO4
Molecular Weight 181.15
Flash Point 218.1ºC
Exact Mass 181.03800
PSA 87.49000
LogP 0.40690
Vapour Pressure 2.07E-08mmHg at 25°C
Index of Refraction 1.607
InChIKey HQPMJFFEXJELOQ-UHFFFAOYSA-N
SMILES O=C(O)Cc1cccnc1C(=O)O

 Synthetic Route

~%

HOMOQUINOLINIC ACID Structure

HOMOQUINOLINIC ACID

CAS#:490-75-5

Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479

~%

HOMOQUINOLINIC ACID Structure

HOMOQUINOLINIC ACID

CAS#:490-75-5

Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479

~%

HOMOQUINOLINIC ACID Structure

HOMOQUINOLINIC ACID

CAS#:490-75-5

Literature: Miescher; Kaegi Helvetica Chimica Acta, 1941 , vol. 24, p. 1471,1479

 HOMOQUINOLINIC ACIDBioassay

View more

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
Name: Human GluN2A (Ionotropic glutamate receptors)
Source: IUPHAR-DB
Target: GluN2A (Ionotropic glutamate receptors) [Homo sapiens]
External Id: 456_Human
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2mCherry
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
Name: Ability to displace [3H]CPP from NMDA receptor in rat brain membrane
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 3A
External Id: CHEMBL748107
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
Name: qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ...
Source: NCGC
Target: 67.9K protein [Vaccinia virus]
External Id: Vaccinia-p2Venus
Total 30, Current Page 1 of 3
1
2
3

 Synonyms

Homoquinolinate
Bromocriptine mesylate
Homoquinolinic acid
Tocris-0197
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.