5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

Modify Date: 2025-08-25 11:02:07

5-Bromo-4-hydroxy-3-biphenylcarboxylic acid structure	Common Name	5-Bromo-4-hydroxy-3-biphenylcarboxylic acid
	CAS Number	4906-68-7	Molecular Weight	293.113
	Density	1.6±0.0 g/cm3	Boiling Point	439.2±0.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₉BrO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	219.4±0.0 °C

Use of 5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1].

Name	3-bromo-2-hydroxy-5-phenylbenzoic acid
Synonym	More Synonyms

Description	AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Ki: 4 nM (AKR1C1), 87 nM (AKR1C2), 4.2 μM (AKR1C3), 18.2 μM (AKR1C4)[1]
In Vitro	AKR1C1-IN-1 potently inhibits the metabolism of progesterone in AKR1C1-overexpressed BAECs, and with an IC50 of 460 nM[1].
References	[1]. El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.

Density	1.6±0.0 g/cm3
Boiling Point	439.2±0.0 °C at 760 mmHg
Molecular Formula	C₁₃H₉BrO₃
Molecular Weight	293.113
Flash Point	219.4±0.0 °C
Exact Mass	291.974000
PSA	57.53000
LogP	4.43
Vapour Pressure	0.0±0.0 mmHg at 25°C
Index of Refraction	1.663
InChIKey	XVZSXNULHSIRCQ-UHFFFAOYSA-N
SMILES	O=C(O)c1cc(-c2ccccc2)cc(Br)c1O

[1,1-Biphenyl]-...

CAS#:323-87-5

5-Bromo-4-hydro...

CAS#:4906-68-7

Literature: Dow Chem. Co. Patent: US2779785 , 1952 ;

Precursor 1
CAS#:323-87-5 [1,1-Biphenyl]-...
DownStream 0

Name: Inhibition of human recombinant 20-alpha HSD expressed in BAEC assessed as inhibition...
Source: ChEMBL
Target: Aldo-keto reductase family 1 member C1
External Id: CHEMBL968789

Name: Selectivity ratio of Ki for human type 3 3-alpha-HSD to Ki for human 20-alpha HSD
Source: ChEMBL
Target: N/A
External Id: CHEMBL980738

Name: Inhibition of PTP1B
Source: ChEMBL
Target: Tyrosine-protein phosphatase non-receptor type 1
External Id: CHEMBL905766

Name: Selectivity ratio of Ki for human type 1 3-alpha-HSD to Ki for human 20-alpha HSD
Source: ChEMBL
Target: N/A
External Id: CHEMBL968788

Name: Selectivity ratio of Ki for human type 2 3-alpha-HSD to Ki for human 20-alpha HSD
Source: ChEMBL
Target: N/A
External Id: CHEMBL968787

Name: Selectivity ratio of Ki for human AKR1C1 Leu308Val mutant to Ki for human wild type A...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1285649

Name: Selectivity ratio of Ki for human AKR1C1 Leu308Ala mutant to Ki for human wild type A...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1285650

Name: Inhibition of human AKR1C2 dehydrogenase activity by fluorometric assay
Source: ChEMBL
Target: Aldo-keto reductase family 1 member C2
External Id: CHEMBL1285651

Name: Selectivity ratio of IC50 of human recombinant AKR1C3 to IC50 of human recombinant AK...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2175573

Name: Selectivity ratio of Ki for human AKR1C2 to Ki for human AKR1C1
Source: ChEMBL
Target: N/A
External Id: CHEMBL1285652

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5-Brom-4-hydroxy-biphenyl-3-carbonsaeure

5-bromo-4-hydroxy-biphenyl-3-carboxylic acid

3-bromo-5-phenylsalicylic acid

3-Bromo-5-phenylsalicylc acid

5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

3'-Bromo-4-hydroxy-3-biphenylcarboxylic acid

[1,1'-biphenyl]-3-carboxylic acid,5-bromo-4-hydroxy

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5-Bromo-4-hydroxy-3-biphenylcarboxylic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [1,1'-Biphenyl]-3-carboxylicacid, 5-bromo-4-hydroxy-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Use of 5-Bromo-4-hydroxy-3-biphenylcarboxylic acid

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.