(-)-norephedrine

Modify Date: 2025-08-21 11:28:44

(-)-norephedrine structure	Common Name	(-)-norephedrine
	CAS Number	492-41-1	Molecular Weight	151.206
	Density	1.1±0.1 g/cm3	Boiling Point	288.1±20.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₃NO	Melting Point	51-53 °C(lit.)
	MSDS	Chinese USA	Flash Point	128.1±21.8 °C
	Symbol	GHS07	Signal Word	Warning

Name	(1R,2S)-2-amino-1-phenylpropan-1-ol
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	288.1±20.0 °C at 760 mmHg
Melting Point	51-53 °C(lit.)
Molecular Formula	C₉H₁₃NO
Molecular Weight	151.206
Flash Point	128.1±21.8 °C
Exact Mass	151.099716
PSA	46.25000
LogP	0.81
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.558
InChIKey	DLNKOYKMWOXYQA-CBAPKCEASA-N
SMILES	CC(N)C(O)c1ccccc1
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC2275000

CHEMICAL NAME :: Norephedrine, (-)-

CAS REGISTRY NUMBER :: 492-41-1

LAST UPDATED :: 199707

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C9-H13-N-O

MOLECULAR WEIGHT :: 151.23

WISWESSER LINE NOTATION :: ZY1&YQR -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 45 mg/kg/30D-I

TOXIC EFFECTS :: Cardiac - cardiomyopathy including infarction Cardiac - EKG changes not diagnostic of specified effects Vascular - BP elevation not characterized in autonomic section

REFERENCE :: AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 28,359,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1071 ug/kg/1D-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - euphoria Behavioral - toxic psychosis

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 11,295,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - headache

REFERENCE :: AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 138,683,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 289,591,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 714 ug/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,60,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Behavioral - headache

REFERENCE :: NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 36,593,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1538 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,132,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,138,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,132,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 124 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,139,1945

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 114 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 153,161,1930

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 36,363,1929 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RC2275000
HS Code	2939440000

Precursor 8
CAS#:154170-05-5 (1R,2S)-1-pheny... CAS#:55253-39-9 (R)-1-hydroxy-1... CAS#:79-24-3 Nitroethane CAS#:100-52-7 Benzaldehyde
CAS#:61347-76-0 L-erythro-(1R,2... CAS#:1798-60-3 (R)-1-Hydroxy-1... CAS#:100-46-9 Benzylamine CAS#:141847-69-0 (S,Z)-N-((1S,4R...
DownStream 10
CAS#:3198-15-0 1R,2S-(-)-Norep... CAS#:492-39-7 Cathine CAS#:4187-57-9 (S)-(+)-1-DIMET... CAS#:34566-04-6 (S)-2-AMINO-5-M...
CAS#:187324-63-6 (1R,2S)-2-[N-Be... CAS#:30275-30-0 2,6-DIHYDROXYBE... CAS#:937-52-0 (R)-4-PHENYLBUT... CAS#:30339-30-1 2-(4-Methylphen...
CAS#:299-42-3 L-(-)-Ephedrine CAS#:187324-66-9 PROPIONIC ACID ...

HS Code	2939440000

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Forensic analysis of hallucinogenic mushrooms and khat (Catha edulis Forsk) using cation-exchange liquid chromatography.

Forensic Sci. Int. 195(1-3) , 160-4, (2010)

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Intern. Emerg. Med. 4(3) , 231-3, (2009)

Name: Dose corresponding to a 5 mmHg increase in Intraurethral pressure (IUP) was determine...
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL648635

Name: In vitro percent efficacy of compound was tested in rabbit urethra
Source: ChEMBL
Target: Oryctolagus cuniculus
External Id: CHEMBL766564

Name: Affinity against 5-hydroxytryptamine receptors in rat fundus model
Source: ChEMBL
Target: 5-hydroxytryptamine receptor 3B
External Id: CHEMBL619177

Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791

Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315

Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979

Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491

Name: Phenotypic Assay to Identify Small Molecules that Upregulate Production of hCFTR in H...
Source: Southern Research Institute
Target: CFTR
External Id: CF Folding

Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Total 31, Current Page 1 of 4

(-)-Norephedrin

MFCD00066044

(1S,2R)-H2NCH(Me)CH(OH)Ph

l-Norephedrine

(-)-Phenylpropanolamine

(-)-erythro-2-Amino-2-methyl-1-phenylethanol

(1R,2S)-2-amino-1-phenyl-propan-1-ol

(1R,2S)-(-)-norephedrine

(1R,2S)-2-Amino-1-phenyl-1-propanol

(aR)-a-[(1S)-1-Aminoethyl]benzenemethanol

USAF CS-6

l-Phenylpropanolamine

L-ERYTHRO-(1R,2S)-2-AMINO-1-PHENYLPROPAN-1-OL

Mydriatin

EINECS 207-755-7

(R,S)-(-)-Norephedrine

(-)-norephedrine

(1R,2S)-2-amino-1-phenylpropan-1-ol

[R-(R*,S*)]-a-(1-Aminoethyl)benzenemethanol

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(-)-norephedrineBioassay

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.