Docosanedioic acid

Modify Date: 2024-01-04 17:23:14

Docosanedioic acid Structure
Docosanedioic acid structure
Common Name Docosanedioic acid
CAS Number 505-56-6 Molecular Weight 370.566
Density 1.0±0.1 g/cm3 Boiling Point 527.0±23.0 °C at 760 mmHg
Molecular Formula C22H42O4 Melting Point 72-80 °C(lit.)
MSDS Chinese USA Flash Point 286.6±19.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Docosanedioic acid


Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

 Names

Name docosanedioic acid
Synonym More Synonyms

 Docosanedioic acid Biological Activity

Description Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 527.0±23.0 °C at 760 mmHg
Melting Point 72-80 °C(lit.)
Molecular Formula C22H42O4
Molecular Weight 370.566
Flash Point 286.6±19.1 °C
Exact Mass 370.308319
PSA 74.60000
LogP 8.24
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.474
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR UN 1824
WGK Germany 3
HS Code 2917190090

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

1,22-Docosanedioic acid
1,20-Eicosanedicarboxylic acid
Phellogenic acid
docosanedicarboxylic acid
MFCD00002807
docosandioic acid
EINECS 204-010-8
Phelogenic acid
Docosanedioic acid
1,22-Docosanedoic acid
Docosandisaeure
Felogenic acid
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