CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XI0186000
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CHEMICAL NAME :
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4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((hexahydro-1H-azepin-1-yl)methylene) amino)-3,3-dimethyl-7-oxo-, 1-((ethoxycarbonyl)oxy)ethyl ester, (2S-(2-alpha,5-alpha,6-beta))-
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CAS REGISTRY NUMBER :
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50846-45-2
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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4
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MOLECULAR FORMULA :
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C20-H31-N3-O6-S
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MOLECULAR WEIGHT :
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441.60
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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11200 mg/kg/35D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
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REFERENCE :
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NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 33(Suppl 3),60,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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57600 mg/kg/26W-I
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
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REFERENCE :
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NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 33(Suppl 3),60,1985 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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4950 mg/kg
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SEX/DURATION :
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female 7-17 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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REFERENCE :
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NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 33(Suppl 3),78,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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35100 mg/kg
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SEX/DURATION :
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female 17 day(s) after conception - 21 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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REFERENCE :
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NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 33(Suppl 3),78,1985
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