Gelsemine

Modify Date: 2024-01-05 01:34:41

Gelsemine structure	Common Name	Gelsemine
	CAS Number	509-15-9	Molecular Weight	322.401
	Density	1.3±0.1 g/cm3	Boiling Point	493.4±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₂N₂O₂	Melting Point	181-183ºC
	MSDS	N/A	Flash Point	252.2±28.7 °C

Use of Gelsemine

Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive and hypnotic effects.

Name	Gelsemine
Synonym	More Synonyms

Description	Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive and hypnotic effects.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease
In Vivo	Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice[1]. Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%[1].
References	[1]. Wu YE, et al. Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice. Acta Pharmacol Sin. 2015 Nov;36(11):1308-17.

Density	1.3±0.1 g/cm3
Boiling Point	493.4±45.0 °C at 760 mmHg
Melting Point	181-183ºC
Molecular Formula	C₂₀H₂₂N₂O₂
Molecular Weight	322.401
Flash Point	252.2±28.7 °C
Exact Mass	322.168121
PSA	41.57000
LogP	3.08
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.673

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LX9100000

CHEMICAL NAME :: Gelsemine

CAS REGISTRY NUMBER :: 509-15-9

BEILSTEIN REFERENCE NO. :: 5406576

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H22-N2-O2

MOLECULAR WEIGHT :: 322.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DUSA** "Dispensatory of the United States of America," 24th ed., Osol, A. and G.E. Farrar, Philadelphia, J.B. Lippincott Co., 1947 Volume(issue)/page/year: 24,497,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,349,1957

Hazard Codes	T+
Risk Phrases	23/24/25-26/27/28
Safety Phrases	36/37/39-45-28
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	LX9100000
Packaging Group	I
Hazard Class	6.1(a)

Precursor 1
CAS#:55856-53-6 21-oxogelsemine
DownStream 0

GELSAMINE

8abeta,9s*,10s*))-8alph

GESEMINE

(2'S,3S,5'S,6'R,8'R,11'S)-4'-Methyl-2'-vinylspiro[indole-3,7'-[9]oxa[4]azatetracyclo[6.3.1.0.0]dodecan]-2(1H)-one

gelsemine free base

Gelsemin

EINECS 208-095-2

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Gelsemine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Gelsemine
Price: ￥Inquiry/5mg
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gelsemine
Price: ￥1258.0/20mg
Purity: 98.0%
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Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Gelsemine
Price: $280.0/20mg
Purity: 98.0%
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Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: GELSEMINE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥702/5mg

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Gelsemine

Use of Gelsemine

Names

Gelsemine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Precursor & DownStream

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