ACONINE
Modify Date: 2025-08-22 10:54:41
ACONINE structure
|
Common Name | ACONINE | ||
|---|---|---|---|---|
| CAS Number | 509-20-6 | Molecular Weight | 499.594 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 626.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H41NO9 | Melting Point | 129-131ºC | |
| MSDS | N/A | Flash Point | 332.4±31.5 °C | |
Use of ACONINEAconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced NF-κB activation. |
| Name | Aconine |
|---|---|
| Synonym | More Synonyms |
| Description | Aconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced NF-κB activation. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | Treatment with Aconine significantly inhibits the RANKL-induced transcriptional activity of NF-κB in a dose-dependent manner. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing the activation of NF-κB and NFATc1 and the expression of the cell-cell fusion molecule DC-STAMP. Aconine (0.125, 0.25 μM) does not affect the viability of RAW264.7 cells, but dose-dependently inhibits RANKL-induced osteoclast formation and bone resorptive activity. Aconine dose-dependently inhibits the RANKL-induced activation of NF-κB and NFATc1 in RAW264.7 cells, and subsequently reduces the expression of osteoclast-specific genes (c-Src, β3-Integrin, cathepsin K and MMP-9) and the expression of dendritic cell-specific transmembrane protein (DC-STAMP), which plays an important role in cell-cell fusion[1]. |
| Cell Assay | To evaluate the effect of Aconine on the viability of RAW264.7 cells, cytotoxicity assays are performed using the Cell Counting Kit-8. Briefly, the cells are seeded in 96-well plates at a density of 2×104, 3×103, 1.2×103, 1×103 or 1×103 cells/well in the presence or absence of Aconine (0.125-0.5 mM) for 8 h, 24 h, 48 h, 5 d or 7 d, respectively. After incubating the cells with CCK-8 solution for 2 h, optical density is measured at 450 nm using a GENios microplate reader. Cell viability is expressed as a percentage of the control[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 626.1±55.0 °C at 760 mmHg |
| Melting Point | 129-131ºC |
| Molecular Formula | C25H41NO9 |
| Molecular Weight | 499.594 |
| Flash Point | 332.4±31.5 °C |
| Exact Mass | 499.278137 |
| PSA | 141.31000 |
| LogP | -1.63 |
| Vapour Pressure | 0.0±4.1 mmHg at 25°C |
| Index of Refraction | 1.624 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| (1a,3a,6a,14a,15a,16b)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol |
| ACONINE |
| Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)- |
| (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol |
| Jesaconine |
| Aconitysat |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ACONINE
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- China
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- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Aconine
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Aconine
- Price: $450.0/25mg $700.0/50mg $1300.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: $244/10mM*1mLinDMSO
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