KRP-203 hydrochloride

Modify Date: 2024-01-19 17:46:15

KRP-203 hydrochloride Structure
KRP-203 hydrochloride structure
 Common Name KRP-203 hydrochloride
CAS Number 509088-69-1 Molecular Weight 480.447
Density N/A Boiling Point 657.1ºC at 760 mmHg
Molecular Formula C24H27Cl2NO3S Melting Point 199-200ºC (DEC.)
MSDS N/A Flash Point 351.2ºC

 Use of KRP-203 hydrochloride


Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2].

 Names

Name 2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol,hydrochloride
Synonym More Synonyms

 KRP-203 hydrochloride Biological Activity

Description Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2].
Target

S1PR1[1]

In Vivo Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R−/− Mice[1]. Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2]. Animal Model: Inbred male DA (MHC haplotype: RT1a) rats[2] Dosage: 0.1 and 1 mg/kg Administration: Orally; daily; for 100 days Result: Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts.
References

[1]. Potì F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.

[2]. Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10.

 Chemical & Physical Properties

Boiling Point 657.1ºC at 760 mmHg
Melting Point 199-200ºC (DEC.)
Molecular Formula C24H27Cl2NO3S
Molecular Weight 480.447
Flash Point 351.2ºC
Exact Mass 479.108856
PSA 101.01000
LogP 6.18720

 Synonyms

1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1)
KRP-203 hydrochloride
2-Amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]-1,3-propanediol hydrochloride (1:1)
KRP-203
2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride
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