Agoniadin

Modify Date: 2024-01-02 15:50:34

Agoniadin Structure
Agoniadin structure
Common Name Agoniadin
CAS Number 511-89-7 Molecular Weight 470.42
Density 1.6±0.1 g/cm3 Boiling Point 771.4±60.0 °C at 760 mmHg
Molecular Formula C21H26O12 Melting Point 156-158°; mp 224-225°
MSDS Chinese USA Flash Point 269.2±26.4 °C

 Use of Agoniadin


Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL[1].

 Names

Name methyl (1S,4aS,7R,7aS)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[4a,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-furan]-4-carboxylate
Synonym More Synonyms

 Agoniadin Biological Activity

Description Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL[1].
Related Catalog
References

[1]. Tiwari TN, et al. Plumieride from Allamanda cathartica as an antidermatophytic agent. Phytother Res. 2002 Jun;16(4):393-4.  

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 771.4±60.0 °C at 760 mmHg
Melting Point 156-158°; mp 224-225°
Molecular Formula C21H26O12
Molecular Weight 470.42
Flash Point 269.2±26.4 °C
Exact Mass 470.142426
PSA 181.44000
LogP -4.23
Vapour Pressure 0.0±6.0 mmHg at 25°C
Index of Refraction 1.645

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles5

More Articles
Assessment of the genotoxic and mutagenic properties of Himatanthus articulatus bark extracts used as phytotherapeutic drug in the Amazon.

J. Ethnopharmacol. 147(2) , 474-80, (2013)

Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.To investigate the in vivo genotoxic...

Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.

J. Nat. Prod. 60(12) , 1294-7, (1997)

Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isopl...

Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity.

J. Org. Chem. 69(19) , 6165-72, (2004)

Plumieride was isolated as one of the major components from the biologically active methanolic extract of the bark of Plumeria bicolor (family Apocynaceae). For investigating the effect of substituent...

 Synonyms

1-(b-D-Glucopyranosyloxy)-4a,7a-dihydro-4'-(1-hydroxyethyl)-5'-oxospiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic Acid Methyl Ester
Spiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-4a,7a-dihydro-4'-[(1S)-1-hydroxyethyl]-5'-oxo-, methyl ester, (1S,4aS,7R,7aS)-
Agoniadin
Methyl (1S,4aS,7R,7aS)-1-(β-D-glucopyranosyloxy)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-4a,7a-dihydro-1H,5'H-spiro[cyclopenta[c]pyran-7,2'-furan]-4-carboxylate
Plumieride
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