Substance P (7-11)

Modify Date: 2024-01-02 03:22:18

Substance P (7-11) Structure
Substance P (7-11) structure
Common Name Substance P (7-11)
CAS Number 51165-05-0 Molecular Weight 612.78300
Density 1.207g/cm3 Boiling Point 1003.3ºC at 760 mmHg
Molecular Formula C31H44N6O5S Melting Point N/A
MSDS N/A Flash Point 560.6ºC

 Use of Substance P (7-11)


Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

 Names

Name N-(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)-2-[[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-phenylpropanoyl]amino]acetyl]amino]-4-methylpentanamide
Synonym More Synonyms

 Substance P (7-11) Biological Activity

Description Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.
Related Catalog
In Vitro Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM[1].
Cell Assay Confluent chondrocytes are incubated for 24 h with SP or Substance P (7-11). TIMP activity is inactivated following reduction and alkylation with 2 mM dithiothreitol and 5 mM iodoacetamide for 30 min at 37°C. Samples are subsequently dialysed. Latent collagenase is activated with 1 mM APt followed by inactivation with soy bean trypsin inhibitor. Collagenase is measured[1].
References

[1]. Halliday DA, et al. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 ( Pt 1):57-62.

 Chemical & Physical Properties

Density 1.207g/cm3
Boiling Point 1003.3ºC at 760 mmHg
Molecular Formula C31H44N6O5S
Molecular Weight 612.78300
Flash Point 560.6ºC
Exact Mass 612.30900
PSA 210.81000
LogP 3.61840
Index of Refraction 1.577
Storage condition 2-8℃

 Synthetic Route

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Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

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Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

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Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

~%

Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

~%

Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

~%

Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

~%

Substance P (7-11) Structure

Substance P (7-11)

CAS#:51165-05-0

Literature: Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247

 Synonyms

Substance P (7-11)
Penta-Substance P
Phe-Phe-Gly-Leu-Met-NH2
SUBSTANCE P,Fragment 7-11
2-{2-[2-(2-amino-3-phenylpropanamido)-3-phenylpropanamido]acetamido}-N-[1-carbamoyl-3-(methylsulfanyl)propyl]-4-methylpentanamide
H-Phe-Phe-Gly-Leu-Met-NH2
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