Substance P (6-11)

Modify Date: 2026-08-06 11:07:19

Substance P (6-11) structure	Common Name	Substance P (6-11)
	CAS Number	51165-07-2	Molecular Weight	740.91200
	Density	1.24g/cm3	Boiling Point	1198.9ºC at 760 mmHg
	Molecular Formula	C₃₆H₅₂N₈O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	678.9ºC

Use of Substance P (6-11)

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Substance P (6-11)
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Substance P(6-11) 在大鼠膀胱中刺激 [3H]-肌醇一磷酸 ([3H]-IP1) 的形成，EC50 值为 4 nM。
In Vivo	Substance P (6-11) (0.1-10 nM) 以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反，在犬胰腺中，Substance P (6-11) (1-10 nM) 会增强胰岛素、胰高血糖素和生长抑素的释放[2]。
References	[1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. [2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.24g/cm3
Boiling Point	1198.9ºC at 760 mmHg
Molecular Formula	C₃₆H₅₂N₈O₇S
Molecular Weight	740.91200
Flash Point	678.9ºC
Exact Mass	740.36800
PSA	283.00000
LogP	3.45990
Index of Refraction	1.579
InChIKey	JRJICHIAKDIPMB-ZIUUJSQJSA-N
SMILES	CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CCC(N)=O)C(N)=O

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Negative log of the concentration producing 50% of the maximum effect was measured in...
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL692366

Name: Negative log of the concentration producing 50% of the maximum effect was measured in...
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL692365

Name: Relative activity was measured in vitro with respect to substance P (SP) in rat colon...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL791404

Name: In vitro potency as spasmogen relative to SP6-11 against rat colon muscularis mucosae
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL882830

Name: The intrinsic activity was measured in guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL687292

Name: Negative log of the concentration producing 50% of the maximum effect was measured in...
Source: ChEMBL
Target: Oryctolagus cuniculus
External Id: CHEMBL773298

Name: The intrinsic activity was measured in Rabbit mesenteric vein
Source: ChEMBL
Target: Oryctolagus cuniculus
External Id: CHEMBL766488

Name: Concentration producing 50% of the maximum effect was tested in guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL685597

Name: The intrinsic activity was measured in guinea pig trachea
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL687293

Name: Relative affinity was determined with substance P(SP) in guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL685564

Total 16, Current Page 1 of 2

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

substance P(6-11)

[Gln6]substance P(6-11)

glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

SUBSTANCE P FRAGMENT 6-11)

L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

HEXA-SUBSTANCE P

SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P

H-GLN-PHE-PHE-GLY-LEU-MET-NH2

GLN-PHE-PHE-GLY-LEU-MET-NH2

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of Substance P (6-11)?

A: Molecular formula of Substance P (6-11) is C36H52N8O7S.

Q: What are the uses of Substance P (6-11)?

A: Main uses of Substance P (6-11): Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

Q: What English synonyms does Substance P (6-11) have?

A: English synonyms of Substance P (6-11): substance P(6-11), [Gln6]substance P(6-11), glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide, SUBSTANCE P FRAGMENT 6-11), L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2, HEXA-SUBSTANCE P, SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P, H-GLN-PHE-PHE-GLY-LEU-MET-NH2, GLN-PHE-PHE-GLY-LEU-MET-NH2.

Q: What is the InChIKey of Substance P (6-11)?

A: InChIKey of Substance P (6-11) is JRJICHIAKDIPMB-ZIUUJSQJSA-N.

Q: What Chinese synonyms does Substance P (6-11) have?

A: Chinese synonyms of Substance P (6-11): GLY-LEU-MET-NH2: GLM-NH2.

Q: What is the polar surface area (PSA) of Substance P (6-11)?

A: Polar surface area (PSA) of Substance P (6-11) is 283.00000.

Q: What is the boiling point of Substance P (6-11)?

A: Boiling point of Substance P (6-11) is 1198.9ºC at 760 mmHg.

Q: What is the LogP of Substance P (6-11)?

A: LogP of Substance P (6-11) is 3.45990.

Q: What is the molecular weight of Substance P (6-11)?

A: Molecular weight of Substance P (6-11) is 740.91200.

Q: What is the Chinese name of 51165-07-2?

A: Chinese name of 51165-07-2 is GLN-PHE-PHE-GLY-LEU-MET-NH2.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SUBSTANCE P (6-11)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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