Substance P (6-11)

Modify Date: 2025-08-27 10:06:20

Substance P (6-11) structure	Common Name	Substance P (6-11)
	CAS Number	51165-07-2	Molecular Weight	740.91200
	Density	1.24g/cm3	Boiling Point	1198.9ºC at 760 mmHg
	Molecular Formula	C₃₆H₅₂N₈O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	678.9ºC

Use of Substance P (6-11)

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

Name	Substance P (6-11)
Synonym	More Synonyms

Description	Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Substance P(6-11) 在大鼠膀胱中刺激 [3H]-肌醇一磷酸 ([3H]-IP1) 的形成，EC50 值为 4 nM。
In Vivo	Substance P (6-11) (0.1-10 nM) 以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反，在犬胰腺中，Substance P (6-11) (1-10 nM) 会增强胰岛素、胰高血糖素和生长抑素的释放[2]。
References	[1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. [2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.

Density	1.24g/cm3
Boiling Point	1198.9ºC at 760 mmHg
Molecular Formula	C₃₆H₅₂N₈O₇S
Molecular Weight	740.91200
Flash Point	678.9ºC
Exact Mass	740.36800
PSA	283.00000
LogP	3.45990
Index of Refraction	1.579
InChIKey	JRJICHIAKDIPMB-ZIUUJSQJSA-N
SMILES	CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CCC(N)=O)C(N)=O

Name: Negative log of the concentration producing 50% of the maximum effect was measured in...
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL692366

Name: Negative log of the concentration producing 50% of the maximum effect was measured in...
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL692365

Name: Relative activity was measured in vitro with respect to substance P (SP) in rat colon...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL791404

Name: In vitro potency as spasmogen relative to SP6-11 against rat colon muscularis mucosae
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL882830

Name: The intrinsic activity was measured in guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL687292

Name: Negative log of the concentration producing 50% of the maximum effect was measured in...
Source: ChEMBL
Target: Oryctolagus cuniculus
External Id: CHEMBL773298

Name: The intrinsic activity was measured in Rabbit mesenteric vein
Source: ChEMBL
Target: Oryctolagus cuniculus
External Id: CHEMBL766488

Name: Concentration producing 50% of the maximum effect was tested in guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL685597

Name: The intrinsic activity was measured in guinea pig trachea
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL687293

Name: Relative affinity was determined with substance P(SP) in guinea pig ileum
Source: ChEMBL
Target: Cavia porcellus
External Id: CHEMBL685564

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substance P(6-11)

[Gln6]substance P(6-11)

glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

SUBSTANCE P FRAGMENT 6-11)

L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2

HEXA-SUBSTANCE P

SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P

H-GLN-PHE-PHE-GLY-LEU-MET-NH2

GLN-PHE-PHE-GLY-LEU-MET-NH2

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