GLN-PHE-PHE-GLY-LEU-MET-NH2

• 常用名: GLN-PHE-PHE-GLY-LEU-MET-NH2
• 英文名: Substance P (6-11)
• CAS号: 51165-07-2
• 分子量: 740.91200
• 密度: 1.24g/cm3
• 沸点: 1198.9ºC at 760 mmHg
• 分子式: C₃₆H₅₂N₈O₇S
• 熔点: N/A
• 闪点: 678.9ºC

GLN-PHE-PHE-GLY-LEU-MET-NH2用途

物质P(6-11)是物质P(物质P(HY-P0201))的C端六肽酰胺。物质P(6-11)与NK-1速激肽受体结合。P物质(6-11)显示运动神经元去极化和降压作用[1][2]。

GLN-PHE-PHE-GLY-LEU-MET-NH2名称

• 中文名: GLN-PHE-PHE-GLY-LEU-MET-NH2
• 英文名: Substance P (6-11)
• 中文别名: GLY-LEU-MET-NH2: GLM-NH2

GLN-PHE-PHE-GLY-LEU-MET-NH2生物活性

• 描述: 物质P(6-11)是物质P(物质P(HY-P0201))的C端六肽酰胺。物质P(6-11)与NK-1速激肽受体结合。P物质(6-11)显示运动神经元去极化和降压作用[1][2]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 神经激肽受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
• 体外研究: 物质P(6-11)在大鼠膀胱中刺激 [3H]-肌醇一磷酸 ([3H]-IP1)的形成,第50周值为 4nM
• 体内研究: 物质P(6-11)(0.1-10 nM)以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反,在犬胰腺中,物质P(6-11)(1-10 nM)会增强胰岛素、胰高血糖素和生长抑素的释放[2]。
• 参考文献:

  [1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51.

  [2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.

GLN-PHE-PHE-GLY-LEU-MET-NH2物理化学性质

• 密度: 1.24g/cm3
• 沸点: 1198.9ºC at 760 mmHg
• 分子式: C₃₆H₅₂N₈O₇S
• 分子量: 740.91200
• 闪点: 678.9ºC
• 精确质量: 740.36800
• PSA: 283.00000
• LogP: 3.45990
• InChIKey: JRJICHIAKDIPMB-ZIUUJSQJSA-N
• SMILES: CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CCC(N)=O)C(N)=O
• 折射率: 1.579

GLN-PHE-PHE-GLY-LEU-MET-NH2靶点实验

查看更多实验

实验名称：Negative log of the concentration producing 50% of the maximum effect was measured in... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL692366

实验名称：Negative log of the concentration producing 50% of the maximum effect was measured in... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL692365

实验名称：Relative activity was measured in vitro with respect to substance P (SP) in rat colon... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL791404

实验名称：In vitro potency as spasmogen relative to SP6-11 against rat colon muscularis mucosae 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL882830

实验名称：The intrinsic activity was measured in guinea pig ileum 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL687292

实验名称：Negative log of the concentration producing 50% of the maximum effect was measured in... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL773298

实验名称：The intrinsic activity was measured in Rabbit mesenteric vein 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL766488

实验名称：Concentration producing 50% of the maximum effect was tested in guinea pig ileum 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685597

实验名称：The intrinsic activity was measured in guinea pig trachea 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL687293

实验名称：Relative affinity was determined with substance P(SP) in guinea pig ileum 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685564

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GLN-PHE-PHE-GLY-LEU-MET-NH2英文别名

• substance P(6-11)
• [Gln6]substance P(6-11)
• glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide
• SUBSTANCE P FRAGMENT 6-11)
• L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
• HEXA-SUBSTANCE P
• SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P
• H-GLN-PHE-PHE-GLY-LEU-MET-NH2
• GLN-PHE-PHE-GLY-LEU-MET-NH2