DMH4

Modify Date: 2026-07-04 13:35:48

DMH4 Structure
DMH4 structure
Common Name DMH4
CAS Number 515880-75-8 Molecular Weight 400.473
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C24H24N4O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of DMH4


DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM[1].

 Names

Name 4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
Synonym More Synonyms

 DMH4 Biological Activity

Description DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM[1].
Related Catalog
Target

VEGFR2:0.16 μM (IC50)

References

[1]. Hao J, et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010 Feb 19;5(2):245-53. 

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C24H24N4O2
Molecular Weight 400.473
Exact Mass 400.189911
PSA 51.89000
LogP 2.12
Index of Refraction 1.653
InChIKey SKZQZGSPYYHTQG-UHFFFAOYSA-N
SMILES c1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport

 Articles1

More Articles
Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.

Biochim. Biophys. Acta 1853(5) , 1154-64, (2015)

We previously identified peptide Lv, a novel bioactive peptide that enhances the activity of L-type voltage-gated calcium channels (L-VGCCs) in cone photoreceptors. In this study, we verified that pep...

 DMH4Bioassay

View more

Name: Inhibition of Vascular endothelial growth factor receptor 2
Source: ChEMBL
Target: Vascular endothelial growth factor receptor 2
External Id: CHEMBL818936
Name: Hit confirmation of the active molecules of the enzymatic assay of human HDAC6 with c...
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808151
Name: in vitro Kinase Assay from Article 10.1021/cb9002865: "In vivo structure-activity rel...
Source: BindingDB
Target: N/A
External Id: BindingDB_3559_4
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
Name: Kinase assay toxicity from Article 10.1021/cb9002865: "In vivo structure-activity rel...
Source: BindingDB
Target: N/A
External Id: BindingDB_3559_3
Name: Kinase assay intersomitic vessel (ISV) disruption from Article 10.1021/cb9002865: "In...
Source: BindingDB
Target: N/A
External Id: BindingDB_3559_2
Total 38, Current Page 1 of 4
1
2
3
4

 Synonyms

6-{4-[2-(4-Morpholinyl)ethoxy]phenyl}-3-phenylpyrazolo[1,5-a]pyrimidine
dmh4
6-{4-[2-(morpholin-4-yl)ethoxy]phenyl}-3-phenylpyrazolo[1,5-a]pyrimidine
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.