taurodeoxycholic acid

Modify Date: 2025-08-21 15:43:10

taurodeoxycholic acid Structure
taurodeoxycholic acid structure
 Common Name taurodeoxycholic acid
CAS Number 516-50-7 Molecular Weight 499.70400
Density N/A Boiling Point N/A
Molecular Formula C26H45NO6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of taurodeoxycholic acid


Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4].

 Names

Name taurodeoxycholic acid
Synonym More Synonyms

 taurodeoxycholic acid Biological Activity

Description Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4].
Related Catalog
Target

Microbial Metabolite

In Vitro Taurodeoxycholic acid (50 μM，100 μM；4 h) 增加原代人肝细胞中寡核体 DNA 切割和细胞核凋亡[1]。 Taurodeoxycholic acid (400 μM；18-24 h) 在人肝来源的 Huh7 细胞中增加 DNA 碎片和 PARP 切割，诱导凋亡[2]。
In Vivo Taurodeoxycholic acid (50 mg/kg；腹腔注射；每天 1 次，共 34 天) 预防亨廷顿舞蹈病 (HD) 大鼠模型的神经病理和相关的行为缺陷[3]。 Taurodeoxycholic acid (500 mg/kg；皮下注射；每 3 天 1 次，共 7 周) 导致 R6/2 转基因 HD 小鼠纹状体神经病理的显著降低[4]。 Animal Model: Huntington's disease model in mouse[3] Dosage: 50 mg/kg Administration: Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment Result: Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions. Significantly improved locomotor and sensorimotor deficits.
References

[1]. Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000 Mar;30(3):203-9.  

[2]. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601.  

[3]. Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001 Oct;171(2):351-60.  

[4]. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6.  

 Chemical & Physical Properties

Molecular Formula C26H45NO6S
Molecular Weight 499.70400
Exact Mass 499.29700
PSA 132.31000
LogP 4.86900
InChIKey AWDRATDZQPNJFN-INWVEICNSA-N
SMILES CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C

 Synthetic Route

Taurine structure

Taurine

CAS#:107-35-7

~%

taurodeoxycholic acid Structure

taurodeoxycholi...

CAS#:516-50-7

Literature: Cortese Journal of the American Chemical Society, 1937 , vol. 59, p. 2532 Full Text View citing articles Show Details Wieland Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1919 , vol. 106, p. 181,185
Taurine structure

Taurine

CAS#:107-35-7

3α,12α-diformyloxy-5β-cholan-24-oic acid chloride structure

3α,12α-diformyl...

CAS#:86678-83-3

~%

taurodeoxycholic acid Structure

taurodeoxycholi...

CAS#:516-50-7

Literature: Cortese; Bashour Journal of Biological Chemistry, 1937 , vol. 119, p. 177,180
Deoxycholic acid structure

Deoxycholic acid

CAS#:83-44-3

~%

taurodeoxycholic acid Structure

taurodeoxycholi...

CAS#:516-50-7

Literature: Norman Arkiv foer Kemi, 1956 , vol. 8, p. 331,338

 taurodeoxycholic acidBioassay

View more

Name: TP_TRANSPORTER: inhibition of Etoposide glucuronide uptake (Etoposide glucuronide: 0....
Source: ChEMBL
Target: ABC-type glutathione-S-conjugate transporter
External Id: CHEMBL2076972
Name: Reduction in human pancreatic recombinant 1B PLA2 activity expressed in Escherichia c...
Source: ChEMBL
Target: Phospholipase A2
External Id: CHEMBL1026212
Name: TP_TRANSPORTER: inhibition of Etoposide glucuronide uptake (Etoposide glucuronide: 0....
Source: ChEMBL
Target: ABC-type glutathione-S-conjugate transporter
External Id: CHEMBL2076973
Name: TP_TRANSPORTER: uptake in ASBT-expressing COS cells
Source: ChEMBL
Target: Ileal sodium/bile acid cotransporter
External Id: CHEMBL2076059
Name: TP_TRANSPORTER: RT-PCR in vivo, liver of CD-1 mouse
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1A4
External Id: CHEMBL2077952
Name: Reduction in human pancreatic recombinant 1B PLA2 activity expressed in Escherichia c...
Source: ChEMBL
Target: Phospholipase A2
External Id: CHEMBL1026996
Name: Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduct...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B1
External Id: CHEMBL2169429
Name: TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurochorate: 10 uM, TDCA: 100 uM)...
Source: ChEMBL
Target: Sodium/bile acid cotransporter
External Id: CHEMBL2077662
Name: Agonist activity at human FXR transfected in human HuH7 cells co-transfected with hum...
Source: ChEMBL
Target: Bile acid receptor
External Id: CHEMBL1027008
Name: Antagonist activity at human FXR transfected in human HuH7 cells co-transfected with ...
Source: ChEMBL
Target: Bile acid receptor
External Id: CHEMBL1027009
Total 54, Current Page 1 of 6
1
2
3
4
5

 Synonyms

taurochenodeoxycholic acid
Deoxycholyltaurine
2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
Tudcabil
Taurodeoxychloic Acid
[3H]-Deoxycholyltaurine
Taurodesoxycholic Acid
Deoxytaurocholic Acid
N-(3a,12a-Dihydroxy-5-cholan-24-oyl)taurine
2-[[(3a,5,12)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

taurodeoxycholic acid suppliers

Price: ￥3400/25 mg

Reference only. check more taurodeoxycholic acid price

Related Compounds: More...
5-(p-Tolyloxy)pentan-1-amine
935659-80-6
2-(1,3-Benzothiazol-2-yl)-2-hydroxyacetic acid
1379355-67-5
2-Methyl-4-[3-(trifluoromethyl)phenyl]benzoic acid
869676-92-6
5-Pentylthiophene-2-boronicacid
1310405-19-6
2-(4-iodo-1,5-dimethyl-1H-pyrazol-3-yl)acetic acid
2757923-13-8
4-Hydroxy-1-(2-hydroxyethyl)-2(1H)-quinolinone
17418-84-7
7-chloro-3-(2-chlorophenyl)-4-hydroxy-2(1H)-quinolone
142326-52-1
1-Butoxy-N,N,N-trimethyl-1-oxo-2-hexadecanaminium bromide
10566-99-1
1-Ethoxy-N,N,N-trimethyl-1-oxo-2-hexadecanaminium chloride
2676-72-4
1-(Benzyloxy)-N,N,N-trimethyl-1-oxo-2-dodecanaminium bromide
10558-34-6
Chemsrc provides taurodeoxycholic acid(CAS#:516-50-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of taurodeoxycholic acid are included as well.>> amp version: taurodeoxycholic acid

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved