5-Hydroxy-2'-deoxyuridine structure
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Common Name | 5-Hydroxy-2'-deoxyuridine | ||
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CAS Number | 5168-36-5 | Molecular Weight | 244.20100 | |
Density | 1.698g/cm3 | Boiling Point | N/A | |
Molecular Formula | C9H12N2O6 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of 5-Hydroxy-2'-deoxyuridine5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase[1]. |
Name | 5-hydroxy-2'-deoxyuridine |
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Synonym | More Synonyms |
Description | 5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase[1]. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | To study the specificity of nucleotide incorporation opposite 5-hydroxypyrimidines in template DNA, 18- and 45-member oligodeoxyribonucleotides, containing an internal 2'-deoxy-5-hydroxyuridine (5-OHdU) in two different sequence contexts, were used. Translesion synthesis past 2'-deoxy-5-hydroxyuridine (5-OHdU) in both oligonucleotides occurred, but pauses both opposite, and one nucleotide prior to, the modified base in the template is observed. The specificity of nucleotide incorporation opposite 2'-deoxy-5-hydroxyuridine (5-OHdU) in the template is sequence context dependent. In one sequence context, dA is the principal nucleotide incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU). However in a second sequence context, dC is the predominant base incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU). In that same sequence context, dC is also the predominant nucleotide incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU)[1]. |
References |
Density | 1.698g/cm3 |
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Molecular Formula | C9H12N2O6 |
Molecular Weight | 244.20100 |
Exact Mass | 244.07000 |
PSA | 124.78000 |
Index of Refraction | 1.654 |
Storage condition | 2-8°C |
Precursor 0 | |
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DownStream 3 | |
Uridine,2'-deoxy-5-hydroxy |
2'-Deoxy-5-hydroxyuridine |
Oh-5-du |