2-Chloro-5-(trifluoromethyl)pyridine

Modify Date: 2025-08-20 17:49:33

2-Chloro-5-(trifluoromethyl)pyridine Structure
2-Chloro-5-(trifluoromethyl)pyridine structure
 Common Name 2-Chloro-5-(trifluoromethyl)pyridine
CAS Number 52334-81-3 Molecular Weight 181.543
Density 1.4±0.1 g/cm3 Boiling Point 171.6±35.0 °C at 760 mmHg
Molecular Formula C6H3ClF3N Melting Point 32-34 °C(lit.)
MSDS Chinese USA Flash Point 57.6±25.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Names

Name 2-Chloro-5-trifluoromethylpyridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 171.6±35.0 °C at 760 mmHg
Melting Point 32-34 °C(lit.)
Molecular Formula C6H3ClF3N
Molecular Weight 181.543
Flash Point 57.6±25.9 °C
Exact Mass 180.990616
PSA 12.89000
LogP 2.44
Vapour Pressure 1.8±0.3 mmHg at 25°C
Index of Refraction 1.447
Storage condition 0-6°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7530000
CHEMICAL NAME :
Pyridine, 2-chloro-5-(trifluoromethyl)-
CAS REGISTRY NUMBER :
52334-81-3
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C6-H3-Cl-F3-N
MOLECULAR WEIGHT :
181.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/m3/6H/4W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5500 mg/kg/21D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
800 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 301,57,1993

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S26-S37/39-S36/37/39
RIDADR 2811
WGK Germany 3
RTECS US7530000
Packaging Group III
Hazard Class 6.1
HS Code 2933399090

 Synthetic Route

3-trifluoromethylpyridine N-oxide structure

3-trifluorometh...

CAS#:22253-72-1

~25%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

2-Chloro-6-trifluoromethylpyridine structure

2-Chloro-6-trif...

CAS#:65753-47-1

Literature: US2012/259125 A1, ; Page/Page column 3 ;
2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE structure

2-HYDROXY-5-(TR...

CAS#:33252-63-0

~%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

Literature: US4249009 A1, ;
2-Chloro-5-trichloromethylpyridine structure

2-Chloro-5-tric...

CAS#:69045-78-9

~53%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

Literature: Heterocycles, , vol. 22, # 1 p. 117 - 124
Sodium trifluoromethanesulphinate structure

Sodium trifluor...

CAS#:2926-29-6

2-Chloro-5-pyridineboronic acid structure

2-Chloro-5-pyri...

CAS#:444120-91-6

~83%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

Literature: Organic Letters, , vol. 14, # 19 p. 4979 - 4981,3 Organic Letters, , vol. 14, # 19 p. 4979 - 4981
2-Chloro-5-iodopyridine structure

2-Chloro-5-iodo...

CAS#:69045-79-0

Triethyl(trifluoromethyl)silane structure

Triethyl(triflu...

CAS#:120120-26-5

~71%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

Literature: Chemical Communications, , # 14 p. 1909 - 1911
Trifluorostibine structure

Trifluorostibine

CAS#:7783-56-4

2-Chloro-5-trichloromethylpyridine structure

2-Chloro-5-tric...

CAS#:69045-78-9

~%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

Literature: US4152328 A1, ;
2-Chloro-5-iodopyridine structure

2-Chloro-5-iodo...

CAS#:69045-79-0

Sodium perfluoroacetate structure

Sodium perfluor...

CAS#:2923-18-4

~86%

2,5-Bis(trifluoromethyl)pyridine structure

2,5-Bis(trifluo...

CAS#:20857-44-7

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 921 - 926
2-Chloro-5-trichloromethylpyridine structure

2-Chloro-5-tric...

CAS#:69045-78-9

~%

2-Chloro-5-(trifluoromethyl)pyridine Structure

2-Chloro-5-(tri...

CAS#:52334-81-3

2-Fluoro-5-(trifluoromethyl)pyridine structure

2-Fluoro-5-(tri...

CAS#:69045-82-5

Literature: European Journal of Medicinal Chemistry, , vol. 24, # 3 p. 249 - 258

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles1

More Articles
Three chloro (trifluoromethyl) pyridines as model substrates for regioexhaustive functionalization. Cottet F and Schlosser M.

European J. Org. Chem. 18 , 3793-98, (2004)

 Synonyms

2-Chloro-5-Trifluoromethylpyridine
EINECS 257-856-5
Pyridine, 2-chloro-5-(trifluoromethyl)-
2-Chloro-5-(trifluoromethyl)pyridine
T6NJ BG EXFFF
MFCD00042225
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