Flucloxacillin

Modify Date: 2024-01-06 14:25:09

Flucloxacillin Structure
Flucloxacillin structure
Common Name Flucloxacillin
CAS Number 5250-39-5 Molecular Weight 453.872
Density 1.6±0.1 g/cm3 Boiling Point 677.3±55.0 °C at 760 mmHg
Molecular Formula C19H17ClFN3O5S Melting Point N/A
MSDS N/A Flash Point 363.4±31.5 °C

 Use of Flucloxacillin


Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2].

 Names

Name flucloxacillin
Synonym More Synonyms

 Flucloxacillin Biological Activity

Description Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2].
Related Catalog
In Vivo Flucloxacillin (200 mg/kg; i.p.; three times/day, for 21 days; male Wistar rats) has effective against the most common bacterial strains in periprosthetic infection[1]. Animal Model: Male Wistar rats[1] Dosage: 200 mg/kg Administration: Intraperitoneal injection; three times/day, for 21 days Result: Reducted germs in the biofilm and in the bone tissue.
References

[1]. Greimel F, et, al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017 Jun 14;11:1729-1736.

[2]. Comber KR, Merrikin DJ, Sutherland R. Antibacterial activity and synergy, in vitro and in vivo, of a combination of amoxycillin and flucloxacillin. Chemotherapy. 1979;25(1):30-9.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 677.3±55.0 °C at 760 mmHg
Molecular Formula C19H17ClFN3O5S
Molecular Weight 453.872
Flash Point 363.4±31.5 °C
Exact Mass 453.056152
PSA 138.04000
LogP 2.60
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.672

 Synonyms

Flucloxacillin
Floxapen
Culpen
(2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Flopen
(2S,5R,6R)-6-({[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Abboflox
EINECS 226-051-0
Flucil
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Flupen
Ladropen
MFCD00864886
Floxacillin
Staphcil
Staphylex
FK 900
Penplus
Stafoxil
BRL 2039
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