5250-39-5

5250-39-5 structure

Name: Flucloxacillin
Chemical Name: flucloxacillin
CAS Number: 5250-39-5
Molecular Formula: C₁₉H₁₇ClFN₃O₅S
Molecular Weight: 453.872
Catalog: API Antibiotics Penicillin
Create Date: 2018-02-13 08:00:00
Modify Date: 2024-01-06 14:25:09
Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2].

Name	flucloxacillin
Synonyms	Flucloxacillin Floxapen Culpen (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Flopen (2S,5R,6R)-6-({[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Abboflox EINECS 226-051-0 Flucil 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- Flupen Ladropen MFCD00864886 Floxacillin Staphcil Staphylex FK 900 Penplus Stafoxil BRL 2039

Description	Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Flucloxacillin (200 mg/kg; i.p.; three times/day, for 21 days; male Wistar rats) has effective against the most common bacterial strains in periprosthetic infection[1]. Animal Model: Male Wistar rats[1] Dosage: 200 mg/kg Administration: Intraperitoneal injection; three times/day, for 21 days Result: Reducted germs in the biofilm and in the bone tissue.
References	[1]. Greimel F, et, al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017 Jun 14;11:1729-1736. [2]. Comber KR, Merrikin DJ, Sutherland R. Antibacterial activity and synergy, in vitro and in vivo, of a combination of amoxycillin and flucloxacillin. Chemotherapy. 1979;25(1):30-9.