Sulfaphenazole

Modify Date: 2024-01-05 07:58:00

Sulfaphenazole Structure
Sulfaphenazole structure
Common Name Sulfaphenazole
CAS Number 526-08-9 Molecular Weight 314.362
Density 1.4±0.1 g/cm3 Boiling Point 541.9±56.0 °C at 760 mmHg
Molecular Formula C15H14N4O2S Melting Point 179-183ºC
MSDS Chinese USA Flash Point 281.5±31.8 °C

 Use of Sulfaphenazole


Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.

 Names

Name sulfaphenazole
Synonym More Synonyms

 Sulfaphenazole Biological Activity

Description Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial.
Related Catalog

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 541.9±56.0 °C at 760 mmHg
Melting Point 179-183ºC
Molecular Formula C15H14N4O2S
Molecular Weight 314.362
Flash Point 281.5±31.8 °C
Exact Mass 314.083740
PSA 98.39000
LogP 1.52
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.684

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA9520000
CHEMICAL NAME :
Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-
CAS REGISTRY NUMBER :
526-08-9
BEILSTEIN REFERENCE NO. :
0308518
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C15-H14-N4-O2-S
MOLECULAR WEIGHT :
314.39
WISWESSER LINE NOTATION :
T5NNJ BR& CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
525 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3016 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,387,1982

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DA9520000
HS Code 2935009090

 Synthetic Route

~%

Sulfaphenazole Structure

Sulfaphenazole

CAS#:526-08-9

Literature: CIBA Patent: US2858309 , 1957 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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 Synonyms

Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-
MFCD00057226
EINECS 208-384-3
4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide
4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Sulfaphenazole
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