Huwentoxin-IV
Modify Date: 2024-01-09 16:58:14
Huwentoxin-IV structure
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Common Name | Huwentoxin-IV | ||
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| CAS Number | 526224-73-7 | Molecular Weight | 4106.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C174H278N52O51S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Huwentoxin-IVHuwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2]. |
| Name | Huwentoxin-IV |
|---|
| Description | Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2]. |
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| Related Catalog | |
| Target |
IC50: 26 nM (Nav1.7), 150 nM (Nav1.2), 338 nM (Nav1.3), 400 nM (Nav1.4)[1] |
| References |
| Molecular Formula | C174H278N52O51S6 |
|---|---|
| Molecular Weight | 4106.78 |