Huwentoxin-IV
Modify Date: 2025-09-28 23:11:39
Huwentoxin-IV structure
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Common Name | Huwentoxin-IV | ||
|---|---|---|---|---|
| CAS Number | 526224-73-7 | Molecular Weight | 4106.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C174H278N52O51S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Huwentoxin-IVHuwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2]. |
| Name | Huwentoxin-IV |
|---|
| Description | Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain[1][2]. |
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| Related Catalog | |
| Target |
IC50: 26 nM (Nav1.7), 150 nM (Nav1.2), 338 nM (Nav1.3), 400 nM (Nav1.4)[1] |
| References |
| Molecular Formula | C174H278N52O51S6 |
|---|---|
| Molecular Weight | 4106.78 |
| InChIKey | MJMLBAPXMAOKDU-UHFFFAOYSA-N |
| SMILES | CCC(C)C(NC(=O)C(CCC(N)=O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCCN)NC(=O)C1CSSCC2NC(=O)C(CCC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C3CCCN3C(=O)C(CC(N)=O)NC(=O)C3CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CSSCC(NC(=O)C(N)CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(Cc4ccccc4)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)N3)NC2=O)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O |