Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-

Modify Date: 2024-01-02 18:50:56

Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)- structure	Common Name	Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-
	CAS Number	53-02-1	Molecular Weight	366.49200
	Density	1.253g/cm3	Boiling Point	65-67ºC(lit.)
	Molecular Formula	C₂₁H₃₄O₅	Melting Point	-108ºC(lit.)
	MSDS	N/A	Flash Point	297.6ºC

Use of Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-

Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].

Name	tetrahydrocortisol
Synonym	More Synonyms

Description	Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
Target	Human Endogenous Metabolite
References	[1]. Webster SP, et al. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408. [2]. Turpeinen U, et al. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 2006;66(2):147-59.

Description

Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].

Target

Human Endogenous Metabolite

References

[1]. Webster SP, et al. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol. 2017 Mar;174(5):396-408.

[2]. Turpeinen U, et al. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 2006;66(2):147-59.

Density	1.253g/cm3
Boiling Point	65-67ºC(lit.)
Melting Point	-108ºC(lit.)
Molecular Formula	C₂₁H₃₄O₅
Molecular Weight	366.49200
Flash Point	297.6ºC
Exact Mass	366.24100
PSA	97.99000
LogP	1.65330
Index of Refraction	n20/D 1.407(lit.)
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4460000

CHEMICAL NAME :: 5-beta-Pregnan-20-one, 3-alpha,11-beta,17,21-tetrahydroxy-

CAS REGISTRY NUMBER :: 53-02-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H34-O5

MOLECULAR WEIGHT :: 366.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

Hazard Codes	Xi
Risk Phrases	36/37
RIDADR	UN 2056 3/PG 2
RTECS	LU5950000

5beta-Tetrahydrocortisol

Urocortisol

3alpha,5beta-Tetrahydrocortisol

Cortisol,tetrahydro

Tetrahydro F

Tetrahydrohydrocortisone

Tetrahydrocompound F

2-hydroxy-1-[(3R,5R,8S,9S,10S,11S,13S,14S,17R)-3,11,17-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

Ba 2682

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Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-

Use of Pregnan-20-one,3,11,17,21-tetrahydroxy-, (3a,5b,11b)-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synonyms

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