Oxandrolone

Modify Date: 2025-08-23 09:57:02

Oxandrolone Structure
Oxandrolone structure
Common Name Oxandrolone
CAS Number 53-39-4 Molecular Weight 306.440
Density 1.1±0.1 g/cm3 Boiling Point 444.4±45.0 °C at 760 mmHg
Molecular Formula C19H30O3 Melting Point 235-238°C
MSDS Chinese USA Flash Point 179.1±21.5 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Effect of Oxandrolone


 

 Names

Name (1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 444.4±45.0 °C at 760 mmHg
Melting Point 235-238°C
Molecular Formula C19H30O3
Molecular Weight 306.440
Flash Point 179.1±21.5 °C
Exact Mass 306.219482
PSA 46.53000
LogP 3.33
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.526
InChIKey QSLJIVKCVHQPLV-PEMPUTJUSA-N
SMILES CC12COC(=O)CC1CCC1C2CCC2(C)C1CCC2(C)O

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RN6800700
CHEMICAL NAME :
2-Oxa-5-alpha-androstan-3-one, 17-beta-hydroxy-17-methyl-
CAS REGISTRY NUMBER :
53-39-4
LAST UPDATED :
199504
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C19-H30-O3
MOLECULAR WEIGHT :
306.49
WISWESSER LINE NOTATION :
T E5 B666 OVOTJ A1 E1 FQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,418,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4893 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,418,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,418,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1832 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,418,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
922 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,418,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,418,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,149,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1800 mg/kg
SEX/DURATION :
female 2-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 22,735,1971
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
70 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,489,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
300 mg/kg
SEX/DURATION :
female 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
RPHRA6 Recent Progress In Hormone Research. Proceedings of the Laurentian Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1947- Volume(issue)/page/year: 20,395,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6171 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H312 + H332-H360
Precautionary Statements P201-P261-P280-P308 + P313
Hazard Codes T
Risk Phrases 60-63-20/21/22
Safety Phrases 22-36/37/39-45
RIDADR NONH for all modes of transport
RTECS RN6800700
HS Code 2937290022

 Customs

HS Code 2937290022

 Articles33

More Articles
Screening for anabolic steroids in sports: analytical strategy based on the detection of phase I and phase II intact urinary metabolites by liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1389 , 65-75, (2015)

In order to improve the detection capabilities of anabolic androgenic steroids (AAS) in sports, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) screening method for the simultaneous detect...

Screening for anabolic steroids in urine of forensic cases using fully automated solid phase extraction and LC-MS-MS.

J. Anal. Toxicol. 38(9) , 637-44, (2014)

A screening method for 18 frequently measured exogenous anabolic steroids and the testosterone/epitestosterone (T/E) ratio in forensic cases has been developed and validated. The method involves a ful...

Mass spectrometric behavior of anabolic androgenic steroids using gas chromatography coupled to atmospheric pressure chemical ionization source. Part I: ionization.

J. Mass Spectrom. 49(6) , 509-21, (2014)

The detection of anabolic androgenic steroids (AAS) is one of the most important topics in doping control analysis. Gas chromatography coupled to (tandem) mass spectrometry (GC-MS(/MS)) with electron ...

 OxandroloneBioassay

View more

Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909317
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909316
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909319
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909318
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909320
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909309
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909308
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909311
Name: Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effec...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909310
Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr
Total 76, Current Page 1 of 8
1
2
3
4
5

 Synonyms

Oxandrin
17β-Hydroxy-17-methyl-2-oxa-5α-androstan-3-one
(5a,17b)-17-Hydroxy-17-methyl-2-oxaandrostan-3-one
Protivar
oxandrolone
Vasorome
Lonavar
Anavar
Oxandrolonum
Oxandrolona
EINECS 200-172-9
(4aS,4bS,6aS,7S,9aS,9bR,11aS)-7-Hydroxy-4a,6a,7-trimethyltetradecahydroindeno[4,5-h]isochromen-2(1H)-one
Dodecahydro-3-hydroxy-6-(hydroxymethyl)-3,3a,6-trimethyl-1H-benz[e]indene-7-acetic Acid d-Lactone
Provitar
Ossandrolone
MFCD00198944
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.