Nicotinamide adenine dinucleotide phosphate

Modify Date: 2026-07-01 20:42:12

Nicotinamide adenine dinucleotide phosphate Structure
Nicotinamide adenine dinucleotide phosphate structure
 Common Name Nicotinamide adenine dinucleotide phosphate
CAS Number 53-59-8 Molecular Weight 743.4
Density N/A Boiling Point N/A
Molecular Formula C21H28N7O17P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nicotinamide adenine dinucleotide phosphate


NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP+) and reduced (NADPH).

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name NADP zwitterion
Synonym More Synonyms

  Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP+) and reduced (NADPH).
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Zhao FL, et al. A genetically encoded biosensor for in vitro and in vivo detection of NADP+. Biosens Bioelectron. 2016 Mar 15;77:901-6.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula C21H28N7O17P3
Molecular Weight 743.4
Exact Mass 743.07545344
PSA 397.05000
LogP -7.30
InChIKey XJLXINKUBYWONI-NNYOXOHSSA-N
SMILES C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O)C(=O)N
Storage condition −20°C
Water Solubility H2O: 50 mg/mL, clear, slightly yellow

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU3440000
CHEMICAL NAME :
Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-, hydroxide, 5',5'-ester with adenosine 2'- (dihydrogen phosphate) 5'-(trihydrogen pyrophosphate), inner salt
CAS REGISTRY NUMBER :
53-59-8
BEILSTEIN REFERENCE NO. :
3885115
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H28-N7-O17-P3
MOLECULAR WEIGHT :
743.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3166 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,160,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1187 No. of Facilities: 58 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 332 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1187 No. of Facilities: 327 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 4926 (estimated) No. of Female Employees: 3928 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
WGK Germany 3
RTECS UU3440000
HS Code 2924199090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Dissociation rate constant of compound for wild type Escherichia coli dihydrofolate r...
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL668112
Name: Dissociation constant towards DHFR mutant F31W
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL696565
Name: Dissociation constant towards human DHFR mutant hF31S
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL699207
Name: Ratio of Kcat to Km for Listeria monocytogenes HMGR class II using NADPH substrate
Source: ChEMBL
Target: N/A
External Id: CHEMBL1819635
Name: Ratio of Kcat to Km for Streptococcus pneumoniae HMGR class II using NADPH substrate
Source: ChEMBL
Target: N/A
External Id: CHEMBL1819634
Name: Dissociation constant towards human wild type DHFR
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL697609
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
Name: Dissociation constant towards mouse DHFR mutant hF31S
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL734994
Total 19, Current Page 1 of 2
1
2

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

NADPH
NADP-ox
NADP+
COENZYME II
b-Nicotinamide Adenine Dinucleotide Phosphate
cozymaseii
β-Nicotinamide Adenine Dinucleotide Phosphate
TPNH
b-NADP
β-Triphosphopyridine Nucleotide
TPN
Triphosphopyridinnucleotid
3-Carbamoyl-1-b-D-ribofuranosylpyridinium Hydroxide 5'®5'-Ester with Adenosine 2'-(Dihydrogen Phosphate) 5'-(Trihydrogen Pyrophosphate) Inner Salt
Co II
Adenosine 5'-(Trihydrogen Diphosphate) 2'-(Dihydrogen Phosphate) P'®5'-Ester with 3-(Aminocarbonyl)-1-b-D-ribofuranosylpyridinium Hydroxide Inner Salt
Beta-NADP,Monopotassium Salt
MFCD10567218
NADP
b-TPN
β-Nicotinamide adenine dinucleotide phosphate (NADP)
Triphosphopyridine Nucleotid
Triphosphopyridine nucleotide

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of NADP zwitterion?
A: Molecular formula of NADP zwitterion is C21H28N7O17P3.
Q: What is the LogP of NADP zwitterion?
A: LogP of NADP zwitterion is -7.30.
Q: What are the uses of NADP zwitterion?
A: Main uses of NADP zwitterion: NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP+) and reduced (NADPH).
Q: What is the CAS number of NADP zwitterion?
A: CAS number of NADP zwitterion is 53-59-8.
Q: What is the English name of NADP zwitterion?
A: The English name of NADP zwitterion is NADP zwitterion.
Q: What are the storage conditions for NADP zwitterion?
A: Storage conditions for NADP zwitterion: −20°C.
Q: What is the molecular weight of NADP zwitterion?
A: Molecular weight of NADP zwitterion is 743.4.
Q: What is the safety information for NADP zwitterion?
A: Safety information for NADP zwitterion: S26-S36.
Q: How is the water solubility of NADP zwitterion?
A: Water solubility of NADP zwitterion: H2O: 50 mg/mL, clear, slightly yellow.
Q: What is the InChIKey of NADP zwitterion?
A: InChIKey of NADP zwitterion is XJLXINKUBYWONI-NNYOXOHSSA-N.

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides CAS#:53-59-8 MSDS, density, melting point, boiling point, structure, etc. Its name is Nicotinamide adenine dinucleotide phosphate>> amp version: Nicotinamide adenine dinucleotide phosphate

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